Obesity and the Gut Microbiome: Striving for Causality

Overview

Journal Mol Metab

Specialty Cell Biology

Date 2013 Sep 12

PMID 24024115

Citations 43

Authors

Isaac T W Harley

Christopher L Karp

Affiliations

Soon will be listed here.

Abstract

The gut microbiome has been proposed to play a causal role in obesity. Here, we review the historical context for this hypothesis, highlight recent key findings, and critically discuss issues central to further progress in the field, including the central epistemological problem for the field: how to define causality in the relationship between microbiota and obesity phenotypes. Definition of such will be critical for the field to move forward.

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