Role of Leptin in Autoimmune Diseases

Overview

Journal Maedica (Bucur)

Specialty General Medicine

Date 2013 Sep 12

PMID 24023603

Citations 13

Authors

Manole Cojocaru

Inimioara Mihaela Cojocaru

Isabela Silosi

Suzana Rogoz

Affiliations

Soon will be listed here.

Abstract

Leptin represents a link between metabolism, nutritional status, and immune responses. Leptin is important for optimal functioning of the immune system. Leptin is a cytokine-like hormone with proinflammatory properties linked to autoimmune diseases. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. Leptin has been shown to enhance immune reactions in autoimmune diseases that are commonly associated with inflammatory responses. Both high and low levels of leptin might contribute to autoimmune diseases. Leptin has been explored as a potential target for therapeutic development in treating autoimmune diseases. In this review, we review here the most recent advances on the role of leptin in autoimmunity and in immune-rheumatological diseases.

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