Solution Structure of the Major G-quadruplex Formed in the Human VEGF Promoter in K+: Insights into Loop Interactions of the Parallel G-quadruplexes

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2013 Sep 6

PMID 24005038

Citations 80

Authors

Prashansa Agrawal

Emmanuel Hatzakis

Kexiao Guo

Megan Carver

Danzhou Yang

Affiliations

Soon will be listed here.

Abstract

Lay Summary: The human VEGF is a key regulator of angiogenesis and plays an important role in tumor survival, growth and metastasis. VEGF overexpression is frequently found in a wide range of human tumors; the VEGF pathway has become an attractive target for cancer therapeutics. DNA G-quadruplexes have been shown to form in the proximal promoter region of VEGF and are amenable to small molecule drug targeting for VEGF suppression. The detailed molecular structure of the major VEGF promoter G-quadruplex reported here will provide an important basis for structure-based rational development of small molecule drugs targeting the VEGF G-quadruplex for gene suppression.

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