Tackling the Physiological Barriers for Successful Mesenchymal Stem Cell Transplantation into the Central Nervous System

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2013 Sep 4

PMID 23998480

Citations 13

Authors

Nathalie De Vocht

Jelle Praet

Kristien Reekmans

Debbie Le Blon

Chloe Hoornaert

Jasmijn Daans

Zwi Berneman

Annemie Van Der Linden

Peter Ponsaerts

Affiliations

Soon will be listed here.

Abstract

Over the past decade a lot of research has been performed towards the therapeutic use of mesenchymal stem cells (MSCs) in neurodegenerative and neuroinflammatory diseases. MSCs have shown to be beneficial in different preclinical studies of central nervous system (CNS) disorders due to their immunomodulatory properties and their capacity to secrete various growth factors. Nevertheless, most of the transplanted cells die within the first hours after transplantation and induce a neuroinflammatory response. In order to increase the efficacy of MSC transplantation, it is thus imperative to completely characterise the mechanisms mediating neuroinflammation and cell death following MSC transplantation into the CNS. Consequently, different components of these cell death- and neuroinflammation-inducing pathways can be targeted in an attempt to improve the therapeutic potential of MSCs for CNS disorders.

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