Biodistribution of Amikacin Solid Lipid Nanoparticles After Pulmonary Delivery

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2013 Aug 29

PMID 23984315

Citations 16

Authors

J Varshosaz

S Ghaffari

S F Mirshojaei

A Jafarian

F Atyabi

F Kobarfard

S Azarmi

Affiliations

Soon will be listed here.

Abstract

The main purpose of the present work was studying the biodistribution of amikacin solid lipid nanoparticles (SLNs) after pulmonary delivery to increase its concentration in the lungs for treatment of cystic fibrosis lung infections and also providing a new method for clinical application of amikacin. To achieve this aim, (99m)Tc labelled amikacin was loaded in cholesterol SLNs and after in vitro optimization, the desired SLNs and free drug were administered through pulmonary and i.v. routes to male rats and qualitative and biodistribution studies were done. Results showed that pulmonary delivery of SLNs of amikacin by microsprayer caused higher drug concentration in lungs than kidneys while i.v. administration of free drug caused reverse conditions. It seems that pulmonary delivery of SLNs may improve patients' compliance due to reduction of drug side effects in kidneys and elongation of drug dosing intervals due to the sustained drug release from SLNs.

Citing Articles

Systemic absorption of liposomal inhaled amikacin in the treatment of resistant : beyond expectations.

Sanchez-Pascual B, Sanchez-Pascual B, Losa-Garcia J, Losa-Garcia J, Sanz-Marquez S, Sanz-Marquez S Rev Esp Quimioter. 2025; 38(2):148-151.

PMID: 40009044 PMC: 11894561. DOI: 10.37201/req/115.2024.

Inhalation Dosage Forms: A Focus on Dry Powder Inhalers and Their Advancements.

Magramane S, Vlahovic K, Gordon P, Kallai-Szabo N, Zelko R, Antal I Pharmaceuticals (Basel). 2023; 16(12).

PMID: 38139785 PMC: 10747137. DOI: 10.3390/ph16121658.

Pulmonary drug delivery for acute respiratory distress syndrome.

Fei Q, Bentley I, Ghadiali S, Englert J Pulm Pharmacol Ther. 2023; 79:102196.

PMID: 36682407 PMC: 9851918. DOI: 10.1016/j.pupt.2023.102196.

Perspectives and Prospective on Solid Lipid Nanoparticles as Drug Delivery Systems.

Madkhali O Molecules. 2022; 27(5).

PMID: 35268643 PMC: 8911793. DOI: 10.3390/molecules27051543.

The quest for a better fight: How can nanomaterials address the current therapeutic and diagnostic obstacles in the fight against COVID-19?.

Ranjbar S, Fatahi Y, Atyabi F J Drug Deliv Sci Technol. 2021; 67:102899.

PMID: 34630635 PMC: 8489264. DOI: 10.1016/j.jddst.2021.102899.

References

Briones E, Colino C, Millan C, Lanao J . Increasing the selectivity of amikacin in rat peritoneal macrophages using carrier erythrocytes. Eur J Pharm Sci. 2009; 38(4):320-4. DOI: 10.1016/j.ejps.2009.08.003. View

Capriles P, Dias A, Costa T, Oliveira M, Faria M, Moura E . Effect of eggplant (Solanum melongena) extract on the in vitro labeling of blood elements with technetium-99m and on the biodistribution of sodium pertechnetate in rats. Cell Mol Biol (Noisy-le-grand). 2003; 48(7):771-6. View

Mansour H, Rhee Y, Wu X . Nanomedicine in pulmonary delivery. Int J Nanomedicine. 2010; 4:299-319. PMC: 2802043. DOI: 10.2147/ijn.s4937. View

Verma R, Kaur J, Kumar K, Yadav A, Misra A . Intracellular time course, pharmacokinetics, and biodistribution of isoniazid and rifabutin following pulmonary delivery of inhalable microparticles to mice. Antimicrob Agents Chemother. 2008; 52(9):3195-201. PMC: 2533446. DOI: 10.1128/AAC.00153-08. View

Pilcer G, Goole J, Van Gansbeke B, Blocklet D, Knoop C, Vanderbist F . Pharmacoscintigraphic and pharmacokinetic evaluation of tobramycin DPI formulations in cystic fibrosis patients. Eur J Pharm Biopharm. 2007; 68(2):413-21. DOI: 10.1016/j.ejpb.2007.05.005. View

Varshosaz J, Ghaffari S, Khoshayand M, Atyabi F, Azarmi S, Kobarfard F . Development and optimization of solid lipid nanoparticles of amikacin by central composite design. J Liposome Res. 2009; 20(2):97-104. DOI: 10.3109/08982100903103904. View

Videira M, Botelho M, Santos A, Gouveia L, de Lima J, Almeida A . Lymphatic uptake of pulmonary delivered radiolabelled solid lipid nanoparticles. J Drug Target. 2003; 10(8):607-13. DOI: 10.1080/1061186021000054933. View

Shah S, Misra A . Liposomal amikacin dry powder inhaler: effect of fines on in vitro performance. AAPS PharmSciTech. 2005; 5(4):e65. PMC: 2750490. DOI: 10.1208/pt050465. View

Ehrmann S, Mercier E, Vecellio L, Ternant D, Paintaud G, Dequin P . Pharmacokinetics of high-dose nebulized amikacin in mechanically ventilated healthy subjects. Intensive Care Med. 2007; 34(4):755-62. DOI: 10.1007/s00134-007-0935-1. View

10.

Sham J, Zhang Y, Finlay W, Roa W, Lobenberg R . Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung. Int J Pharm. 2004; 269(2):457-67. DOI: 10.1016/j.ijpharm.2003.09.041. View

11.

Weers J, Metzheiser B, Taylor G, Warren S, Meers P, Perkins W . A gamma scintigraphy study to investigate lung deposition and clearance of inhaled amikacin-loaded liposomes in healthy male volunteers. J Aerosol Med Pulm Drug Deliv. 2009; 22(2):131-8. DOI: 10.1089/jamp.2008.0693. View

12.

Valenca S, Lima E, Dire G, Bernardo-Filho M, Porto L . Sodium pertechnetate (Na99mTcO4) biodistribution in mice exposed to cigarette smoke. BMC Nucl Med. 2005; 5(1):1. PMC: 1090589. DOI: 10.1186/1471-2385-5-1. View

13.

Xiang Q, Wang M, Chen F, Gong T, Jian Y, Zhang Z . Lung-targeting delivery of dexamethasone acetate loaded solid lipid nanoparticles. Arch Pharm Res. 2007; 30(4):519-25. DOI: 10.1007/BF02980228. View

14.

Jain S, Gupta Y, Ramalingam L, Jain A, Jain A, Khare P . Lactose-Conjugated PLGA Nanoparticles for Enhanced Delivery of Rifampicin to the Lung for Effective Treatment of Pulmonary Tuberculosis. PDA J Pharm Sci Technol. 2011; 64(3):278-87. View

15.

Wang J, Zhu J, Lu R, Shen W . [Preparation of lung targeting azithromycin liposomes and its tissue distribution in mice]. Yao Xue Xue Bao. 2005; 40(3):274-8. View

16.

Millan C, Zarzuelo Castaneda A, Gonzalez Lopez F, Sayalero Marinero M, Lanao J . Pharmacokinetics and biodistribution of amikacin encapsulated in carrier erythrocytes. J Antimicrob Chemother. 2007; 61(2):375-81. DOI: 10.1093/jac/dkm477. View

17.

Cullen A, Cox C, Hipp S, Wolfson M, Shaffer T . Intra-tracheal delivery strategy of gentamicin with partial liquid ventilation. Respir Med. 1999; 93(11):770-8. DOI: 10.1016/s0954-6111(99)90261-5. View