Greater Seasonal Cycling of 25-hydroxyvitamin D is Associated with Increased Parathyroid Hormone and Bone Resorption

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2013 Aug 29

PMID 23982802

Citations 14

Authors

A L Darling

K H Hart

M A Gibbs

F Gossiel

T Kantermann

K Horton

S Johnsen

J L Berry

D J Skene

R Eastell

R Vieth

S A Lanham-New

Affiliations

Soon will be listed here.

Abstract

Summary: This analysis assessed whether seasonal change in 25-hydroxyvitamin D concentration was associated with bone resorption, as evidenced by serum parathyroid hormone and C-terminal telopeptide concentrations. The main finding was that increased seasonal fluctuation in 25-hydroxyvitamin D was associated with increased levels of parathyroid hormone and C-terminal telopeptide.

Introduction: It is established that adequate 25-hydroxyvitamin D (25(OH)D, vitamin D) concentration is required for healthy bone mineralisation. It is unknown whether seasonal fluctuations in 25(OH)D also impact on bone health. If large seasonal fluctuations in 25(OH)D were associated with increased bone resorption, this would suggest a detriment to bone health. Therefore, this analysis assessed whether there is an association between seasonal variation in 25(OH)D and bone resorption.

Methods: The participants were (n = 279) Caucasian and (n = 88) South Asian women (mean (±SD); age 48.2 years (14.4)) who participated in the longitudinal Diet, Food Intake, Nutrition and Exposure to the Sun in Southern England study (2006-2007). The main outcomes were serum 25(OH)D, serum parathyroid hormone (sPTH) and serum C-terminal telopeptide of collagen (sCTX), sampled once per season for each participant.

Results: Non-linear mixed modelling showed the (amplitude/mesor) ratio for seasonal change in log 25(OH)D to be predictive of log sPTH (estimate = 0.057, 95 % CI (0.051, 0.063), p < 0.0001). Therefore, individuals with a higher seasonal change in log 25(OH)D, adjusted for overall log 25(OH)D concentration, showed increased levels of log sPTH. There was a corresponding significant ability to predict the range of seasonal change in log 25(OH)D through the level of sCTX. Here, the corresponding parameter statistics were estimate = 0.528, 95 % CI (0.418, 0.638) and p ≤ 0.0001.

Conclusions: These findings suggest a possible detriment to bone health via increased levels of sPTH and sCTX in individuals with a larger seasonal change in 25(OH)D concentration. Further larger cohort studies are required to further investigate these preliminary findings.

Citing Articles

Life history in primate teeth is revealed by changes in major and minor element concentrations measured via field-emission SEM-EDS analysis.

Cerrito P, Hu B, Kalisher R, Bailey S, Bromage T Biol Lett. 2023; 19(1):20220438.

PMID: 36651149 PMC: 9846430. DOI: 10.1098/rsbl.2022.0438.

Lack of significant seasonal association between serum 25(OH)D concentration, muscle mass and strength in postmenopausal women from the D-FINES longitudinal study.

Welford A, Darling A, Allison S, Lanham-New S, Greig C J Nutr Sci. 2023; 11:e107.

PMID: 36588541 PMC: 9794962. DOI: 10.1017/jns.2022.106.

Bone Turnover Markers: Basic Biology to Clinical Applications.

Schini M, Vilaca T, Gossiel F, Salam S, Eastell R Endocr Rev. 2022; 44(3):417-473.

PMID: 36510335 PMC: 10166271. DOI: 10.1210/endrev/bnac031.

Global differences in vitamin D status and dietary intake: a review of the data.

Cashman K Endocr Connect. 2021; 11(1).

PMID: 34860171 PMC: 8789021. DOI: 10.1530/EC-21-0282.

Vitamin D supplementation: cholecalciferol, calcifediol, and calcitriol.

Vieth R Eur J Clin Nutr. 2020; 74(11):1493-1497.

PMID: 32704098 DOI: 10.1038/s41430-020-0697-1.

References

Lagunova Z, Porojnicu A, Lindberg F, Hexeberg S, Moan J . The dependency of vitamin D status on body mass index, gender, age and season. Anticancer Res. 2009; 29(9):3713-20. View

Anderson P, Sawyer R, Moore A, May B, OLoughlin P, Morris H . Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model. J Bone Miner Res. 2008; 23(11):1789-97. DOI: 10.1359/jbmr.080616. View

Oliveri M, Ladizesky M, Mautalen C, Alonso A, Martinez L . Seasonal variations of 25 hydroxyvitamin D and parathyroid hormone in Ushuaia (Argentina), the southernmost city of the world. Bone Miner. 1993; 20(1):99-108. DOI: 10.1016/s0169-6009(08)80041-4. View

van Driel M, Koedam M, Buurman C, Hewison M, Chiba H, Uitterlinden A . Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells. FASEB J. 2006; 20(13):2417-9. DOI: 10.1096/fj.06-6374fje. View

Vieth R . Enzyme kinetics hypothesis to explain the U-shaped risk curve for prostate cancer vs. 25-hydroxyvitamin D in nordic countries. Int J Cancer. 2004; 111(3):468. DOI: 10.1002/ijc.20218. View

Atkins G, Anderson P, Findlay D, Welldon K, Vincent C, Zannettino A . Metabolism of vitamin D3 in human osteoblasts: evidence for autocrine and paracrine activities of 1 alpha,25-dihydroxyvitamin D3. Bone. 2007; 40(6):1517-28. DOI: 10.1016/j.bone.2007.02.024. View

Anderson P, OLoughlin P, May B, Morris H . Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels. Bone. 2005; 36(4):654-62. DOI: 10.1016/j.bone.2005.01.012. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Lips P . Vitamin D status and nutrition in Europe and Asia. J Steroid Biochem Mol Biol. 2007; 103(3-5):620-5. DOI: 10.1016/j.jsbmb.2006.12.076. View

10.

Greene-Finestone L, Berger C, de Groh M, Hanley D, Hidiroglou N, Sarafin K . 25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates. Osteoporos Int. 2010; 22(5):1389-99. PMC: 5102696. DOI: 10.1007/s00198-010-1362-7. View

11.

Need A, Horowitz M, Morris H, Moore R, Nordin C . Seasonal change in osteoid thickness and mineralization lag time in ambulant patients. J Bone Miner Res. 2007; 22(5):757-61. DOI: 10.1359/jbmr.070203. View

12.

Tuohimaa P, Tenkanen L, Ahonen M, Lumme S, Jellum E, Hallmans G . Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer. 2003; 108(1):104-8. DOI: 10.1002/ijc.11375. View

13.

Darling A, Hart K, Macdonald H, Horton K, Kangombe A, Berry J . Vitamin D deficiency in UK South Asian Women of childbearing age: a comparative longitudinal investigation with UK Caucasian women. Osteoporos Int. 2012; 24(2):477-88. DOI: 10.1007/s00198-012-1973-2. View

14.

Christensen M, Lien E, Hustad S, Almas B . Seasonal and age-related differences in serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D and parathyroid hormone in patients from Western Norway. Scand J Clin Lab Invest. 2010; 70(4):281-6. DOI: 10.3109/00365511003797172. View

15.

Lester E, Skinner R, Wills M . Seasonal variation in serum-25-hydroxyvitamin-D in the elderly in Britain. Lancet. 1977; 1(8019):979-80. DOI: 10.1016/s0140-6736(77)92280-2. View

16.

Kull Jr M, Kallikorm R, Tamm A, Lember M . Seasonal variance of 25-(OH) vitamin D in the general population of Estonia, a Northern European country. BMC Public Health. 2009; 9:22. PMC: 2632995. DOI: 10.1186/1471-2458-9-22. View

17.

Birmingham D, Hebert L, Song H, Noonan W, Rovin B, Nagaraja H . Evidence that abnormally large seasonal declines in vitamin D status may trigger SLE flare in non-African Americans. Lupus. 2012; 21(8):855-64. PMC: 3839052. DOI: 10.1177/0961203312439640. View

18.

MacDonald H, Kontulainen S, Petit M, Janssen P, McKay H . Bone strength and its determinants in pre- and early pubertal boys and girls. Bone. 2006; 39(3):598-608. DOI: 10.1016/j.bone.2006.02.057. View

19.

Mithal A, Wahl D, Bonjour J, Burckhardt P, Dawson-Hughes B, Eisman J . Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009; 20(11):1807-20. DOI: 10.1007/s00198-009-0954-6. View

20.

Vieth R . How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology. Anticancer Res. 2009; 29(9):3675-84. View