Insulin Growth Factor Signaling is Regulated by MicroRNA-486, an Underexpressed MicroRNA in Lung Cancer

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2013 Aug 28

PMID 23980150

Citations 86

Authors

Yong Peng

Yuntao Dai

Charles Hitchcock

Xiaojuan Yang

Edmund S Kassis

Lunxu Liu

Zhenghua Luo

Hui-Lung Sun

Ri Cui

Huijun Wei

Taewan Kim

Tae Jin Lee

Young-Jun Jeon

Gerard J Nuovo

Stefano Volinia

Qianchuan He

Jianhua Yu

Patrick Nana-Sinkam

Carlo M Croce

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are small 19- to 24-nt noncoding RNAs that have the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In cancer, miRNAs may function as oncogenes or tumor suppressors. Here, we conducted global profiling for miRNAs in a cohort of stage 1 nonsmall cell lung cancers (n = 81) and determined that miR-486 was the most down-regulated miRNA in tumors compared with adjacent uninvolved lung tissues, suggesting that miR-486 loss may be important in lung cancer development. We report that miR-486 directly targets components of insulin growth factor (IGF) signaling including insulin-like growth factor 1 (IGF1), IGF1 receptor (IGF1R), and phosphoinositide-3-kinase, regulatory subunit 1 (alpha) (PIK3R1, or p85a) and functions as a potent tumor suppressor of lung cancer both in vitro and in vivo. Our findings support the role for miR-486 loss in lung cancer and suggest a potential biological link to p53.

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