Spectrum of MicroRNAs and Their Target Genes in Cancer: Intervention in Diagnosis and Therapy

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2022 Jan 15

PMID 35031927

Authors

Alti Dayakar

Kumar D Shanmukha

Suresh K Kalangi

Affiliations

Soon will be listed here.

Abstract

Till date, several groups have studied the mechanism of microRNA (miRNA) biogenesis, processing, stability, silencing, and their dysregulation in cancer. The miRNA coding genes recurrently go through abnormal amplification, deletion, transcription, and epigenetic regulation in cancer. Some miRNAs function as tumor promoters while few others are tumor suppressors based on the transcriptional regulation of target genes. A review of miRNAs and their target genes in a wide range of cancers is attempted in this article, which may help in the development of new diagnostic tools and intervention therapies. The contribution of miRNAs for drug sensitivity or resistance in cancer therapy and opportunities of miRNAs in cancer prognosis or diagnosis and therapy is also presented in detail.

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