Novel Isoforms of Periostin Expressed in the Human Thyroid

Overview

Journal Jpn Clin Med

Publisher Sage Publications

Specialty General Medicine

Date 2013 Aug 16

PMID 23946676

Citations 16

Authors

Yanhua Bai

Misa Nakamura

Gengyin Zhou

Yaqiong Li

Zhiyan Liu

Takashi Ozaki

Ichiro Mori

Kennichi Kakudo

Affiliations

Soon will be listed here.

Abstract

Periostin is an extracellular matrix protein. Five isoforms of human periostin cDNA have been reported, but the expression of periostin isoforms in the human thyroid tissue is by far unknown. A group of primer sets were designed to amplify the full length of cDNA sequence of periostin. Using human thyroid carcinoma and their paired non-neoplastic tissues together with anaplastic thyroid carcinoma cell lines, we examined the presence of periostin cDNA isoforms by RT-PCR and direct DNA sequence analysis. We identified eight coexisting cDNA isoforms in all the tissue samples and cell lines. Three of them were unique to this study. Especially two of them haven't been previously reported in any species. The eight periostin isoforms differ in the C-terminus from exon XII to exon XXI where alternative splicing usually happens. This is the first report that demonstrates all the eight isoforms of periostin cDNA expressed in the human thyroid gland and identifies three novel isoforms.

Citing Articles

Development of a top-down MS assay for specific identification of human periostin isoforms.

Rusbjerg-Weberskov C, Gant M, Chamot-Rooke J, Nielsen N, Enghild J Front Mol Biosci. 2024; 11:1399225.

PMID: 38962283 PMC: 11220192. DOI: 10.3389/fmolb.2024.1399225.

Effect of hypoxia‑HIF‑1α‑periostin axis in thyroid cancer.

Yang Y, Wu J, Zhu H, Shi X, Liu J, Li Y Oncol Rep. 2024; 51(4).

PMID: 38391012 PMC: 10915707. DOI: 10.3892/or.2024.8716.

Periostin C-Terminal Is Intrinsically Disordered and Interacts with 143 Proteins in an In Vitro Epidermal Model of Atopic Dermatitis.

Rusbjerg-Weberskov C, Johansen M, Nowak J, Otzen D, Pedersen J, Enghild J Biochemistry. 2023; 62(19):2803-2815.

PMID: 37704583 PMC: 10552548. DOI: 10.1021/acs.biochem.3c00176.

Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma.

Wenhua S, Tsunematsu T, Umeda M, Tawara H, Fujiwara N, Mouri Y Cancer Med. 2023; 12(7):8510-8525.

PMID: 36691359 PMC: 10134278. DOI: 10.1002/cam4.5601.

Periostin expression and its supposed roles in benign and malignant thyroid nodules: an immunohistochemical study of 105 cases.

Kusafuka K, Yamashita M, Iwasaki T, Tsuchiya C, Kubota A, Hirata K Diagn Pathol. 2021; 16(1):86.

PMID: 34563225 PMC: 8465710. DOI: 10.1186/s13000-021-01146-8.

References

Shao R, Bao S, Bai X, Blanchette C, Anderson R, Dang T . Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol. 2004; 24(9):3992-4003. PMC: 387763. DOI: 10.1128/MCB.24.9.3992-4003.2004. View

Gillan L, Matei D, Fishman D, Gerbin C, Karlan B, Chang D . Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. Cancer Res. 2002; 62(18):5358-64. View

Litvin J, Selim A, Montgomery M, Lehmann K, Rico M, Devlin H . Expression and function of periostin-isoforms in bone. J Cell Biochem. 2004; 92(5):1044-61. DOI: 10.1002/jcb.20115. View

Siriwardena B, Kudo Y, Ogawa I, Kitagawa M, Kitajima S, Hatano H . Periostin is frequently overexpressed and enhances invasion and angiogenesis in oral cancer. Br J Cancer. 2006; 95(10):1396-403. PMC: 2360586. DOI: 10.1038/sj.bjc.6603431. View

Yoshioka N, Fuji S, Shimakage M, Kodama K, Hakura A, Yutsudo M . Suppression of anchorage-independent growth of human cancer cell lines by the TRIF52/periostin/OSF-2 gene. Exp Cell Res. 2002; 279(1):91-9. DOI: 10.1006/excr.2002.5590. View

Sasaki H, Dai M, Auclair D, Fukai I, Kiriyama M, Yamakawa Y . Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas. Cancer. 2001; 92(4):843-8. DOI: 10.1002/1097-0142(20010815)92:4<843::aid-cncr1391>3.0.co;2-p. View

Tai I, Dai M, Chen L . Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies. Carcinogenesis. 2005; 26(5):908-15. DOI: 10.1093/carcin/bgi034. View

Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M . Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell. 2004; 5(4):329-39. DOI: 10.1016/s1535-6108(04)00081-9. View

Kudo Y, Siriwardena B, Hatano H, Ogawa I, Takata T . Periostin: novel diagnostic and therapeutic target for cancer. Histol Histopathol. 2007; 22(10):1167-74. DOI: 10.14670/HH-22.1167. View

10.

Bai Y, Kakudo K, Nakamura M, Ozaki T, Li Y, Liu Z . Loss of cellular polarity/cohesiveness in the invasive front of papillary thyroid carcinoma and periostin expression. Cancer Lett. 2009; 281(2):188-95. DOI: 10.1016/j.canlet.2009.02.043. View

11.

Horiuchi K, Amizuka N, Takeshita S, Takamatsu H, Katsuura M, Ozawa H . Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta. J Bone Miner Res. 1999; 14(7):1239-49. DOI: 10.1359/jbmr.1999.14.7.1239. View

12.

Kim C, Yoshioka N, Tambe Y, Kushima R, Okada Y, Inoue H . Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells. Int J Cancer. 2005; 117(1):51-8. DOI: 10.1002/ijc.21120. View

13.

Yan W, Shao R . Transduction of a mesenchyme-specific gene periostin into 293T cells induces cell invasive activity through epithelial-mesenchymal transformation. J Biol Chem. 2006; 281(28):19700-8. DOI: 10.1074/jbc.M601856200. View

14.

Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I . Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology. 2007; 132(4):1447-64. DOI: 10.1053/j.gastro.2007.01.031. View

15.

Kudo Y, Ogawa I, Kitajima S, Kitagawa M, Kawai H, Gaffney P . Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer. Cancer Res. 2006; 66(14):6928-35. DOI: 10.1158/0008-5472.CAN-05-4540. View

16.

Kim C, Isono T, Tambe Y, Chano T, Okabe H, Okada Y . Role of alternative splicing of periostin in human bladder carcinogenesis. Int J Oncol. 2007; 32(1):161-9. View

17.

Takeshita S, Kikuno R, Tezuka K, Amann E . Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 1993; 294 ( Pt 1):271-8. PMC: 1134594. DOI: 10.1042/bj2940271. View

18.

Fluge O, Bruland O, Akslen L, Lillehaug J, Varhaug J . Gene expression in poorly differentiated papillary thyroid carcinomas. Thyroid. 2006; 16(2):161-75. DOI: 10.1089/thy.2006.16.161. View

19.

Puppin C, Fabbro D, Dima M, Di Loreto C, Puxeddu E, Filetti S . High periostin expression correlates with aggressiveness in papillary thyroid carcinomas. J Endocrinol. 2008; 197(2):401-8. DOI: 10.1677/JOE-07-0618. View