Heterogeneous Periostin Expression in Different Histological Variants of Papillary Thyroid Carcinoma

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2018 Feb 14

PMID 29435461

Citations 5

Authors

Simona Eliza Giusca

Cornelia Amalinei

Ludmila Lozneanu

Delia Ciobanu Apostol

Elena Corina Andriescu

Alex Scripcariu

Raluca Balan

Elena Roxana Avadanei

Irina-Draga Caruntu

Affiliations

Soon will be listed here.

Abstract

Background: Periostin (PN) epithelial and stromal overexpression in tumor pathology has been studied according to tumor growth, angiogenesis, invasiveness, and metastasis, but a limited number of studies address PN in thyroid tumors.

Aim: Our study aimed to analyze PN expression in different histological variants of PTC and to correlate its expression with the clinicopathological prognostic factors.

Material And Methods: PN expression has been immunohistochemically assessed in 50 cases of PTC (conventional, follicular, oncocytic, macrofollicular, and tall cell variants), in tumor epithelial cells and intratumoral stroma. The association between PN expression and clinicopathological characteristics has been evaluated.

Results: Our results show that PTC presented different patterns of PN immunoreaction, stromal PN being significantly associated with advanced tumor stage and extrathyroidal extension. No correlations were found between PN overexpression in tumor epithelial cells and clinicopathological features, except for specific histological variants, the highest risk of poor outcome being registered for the conventional subtype in comparison to the oncocytic type.

Conclusions: Our study demonstrates differences in PN expression in histological subtypes of PTC. Our results plead in favor of a dominant protumorigenic role of stromal PN, while the action of epithelial PN is less noticeable.

Citing Articles

Effect of hypoxia‑HIF‑1α‑periostin axis in thyroid cancer.

Yang Y, Wu J, Zhu H, Shi X, Liu J, Li Y Oncol Rep. 2024; 51(4).

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Identifying key genes of classic papillary thyroid cancer in women aged more than 55 years old using bioinformatics analysis.

Li C, Ullah M, Lin X, Shan S, Guo B, Zheng M Front Endocrinol (Lausanne). 2022; 13:948285.

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Thyroid Carcinoma: Phenotypic Features, Underlying Biology and Potential Relevance for Targeting Therapy.

Hu J, Yuan I, Mirshahidi S, Simental A, Lee S, Yuan X Int J Mol Sci. 2021; 22(4).

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Upregulation of sphingosine kinase 1 is associated with recurrence and poor prognosis in papillary thyroid carcinoma.

Li J, Zhang B, Bai Y, Liu Y, Zhang B, Jin J Oncol Lett. 2019; 18(5):5374-5382.

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Distinct expression pattern of periostin splice variants in chondrocytes and ligament progenitor cells.

Cai L, Brophy R, Tycksen E, Duan X, Nunley R, Rai M FASEB J. 2019; 33(7):8386-8405.

PMID: 30991832 PMC: 6593895. DOI: 10.1096/fj.201802281R.

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