The Phosphatase Ptc7 Induces Coenzyme Q Biosynthesis by Activating the Hydroxylase Coq7 in Yeast

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2013 Aug 14

PMID 23940037

Citations 22

Authors

Alejandro Martin-Montalvo

Isabel Gonzalez-Mariscal

Teresa Pomares-Viciana

Sergio Padilla-Lopez

Manuel Ballesteros

Luis Vazquez-Fonseca

Pablo Gandolfo

David L Brautigan

Placido Navas

Carlos Santos-Ocana

Affiliations

Soon will be listed here.

Abstract

The study of the components of mitochondrial metabolism has potential benefits for health span and lifespan because the maintenance of efficient mitochondrial function and antioxidant capacity is associated with improved health and survival. In yeast, mitochondrial function requires the tight control of several metabolic processes such as coenzyme Q biosynthesis, assuring an appropriate energy supply and antioxidant functions. Many mitochondrial processes are regulated by phosphorylation cycles mediated by protein kinases and phosphatases. In this study, we determined that the mitochondrial phosphatase Ptc7p, a Ser/Thr phosphatase, was required to regulate coenzyme Q6 biosynthesis, which in turn activated aerobic metabolism and enhanced oxidative stress resistance. We showed that Ptc7p phosphatase specifically activated coenzyme Q6 biosynthesis through the dephosphorylation of the demethoxy-Q6 hydroxylase Coq7p. The current findings revealed that Ptc7p is a regulator of mitochondrial metabolism that is essential to maintain proper function of the mitochondria by regulating energy metabolism and oxidative stress resistance.

Citing Articles

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PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy.

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