The Cell Biology of Synaptic Specificity During Development

Overview

Journal Curr Opin Neurobiol

Specialties Biology
Neurology

Date 2013 Aug 13

PMID 23932598

Citations 12

Authors

Ryan Christensen

Zhiyong Shao

Daniel A Colon-Ramos

Affiliations

Soon will be listed here.

Abstract

Proper circuit connectivity is critical for nervous system function. Connectivity derives from the interaction of two interdependent modules: synaptic specificity and synaptic assembly. Specificity involves both targeting of neurons to specific laminar regions and the formation of synapses onto defined subcellular areas. In this review, we focus discussion on recently elucidated molecular mechanisms that control synaptic specificity and link them to synapse assembly. We use these molecular pathways to underscore fundamental cell biological concepts that underpin, and help explain, the rules governing synaptic specificity.

Citing Articles

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Survival and Functional Integration of Human Embryonic Stem Cell-Derived Retinal Organoids After Shipping and Transplantation into Retinal Degeneration Rats.

Lin B, Singh R, Seiler M, Nasonkin I Stem Cells Dev. 2024; 33(9-10):201-213.

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Comparison of Developmental Dynamics in Human Fetal Retina and Human Pluripotent Stem Cell-Derived Retinal Tissue.

Singh R, Winkler P, Binette F, Petersen-Jones S, Nasonkin I Stem Cells Dev. 2021; 30(8):399-417.

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Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in the Subretinal Space of the Cat Eye.

Singh R, Occelli L, Binette F, Petersen-Jones S, Nasonkin I Stem Cells Dev. 2019; 28(17):1151-1166.

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Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10.

Venkatasubramanian L, Guo Z, Xu S, Tan L, Xiao Q, Nagarkar-Jaiswal S Elife. 2019; 8.

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