Advances in Diagnosis and Treatment of Hilar Cholangiocarcinoma -- a Review

Overview

Journal Med Sci Monit

Specialties General Medicine
Pathology

Date 2013 Aug 8

PMID 23921971

Citations 14

Authors

Geng Zhimin

Hidayatullah Noor

Zheng Jian-Bo

Wang Lin

Rajiv Kumar Jha

Affiliations

Soon will be listed here.

Abstract

Hilar cholangiocarcinoma (HC) is a rare tumor that causes devastating disease. In the late stages, this carcinoma primarily invades the portal vein and metastasizes to the hepatic lobes; it is associated with a poor prognosis. HC is diagnosed by its clinical manifestation and results of imaging techniques such as ultrasound, computed tomography, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiography, and percutaneous transhepatic cholangiography. Preoperative hepatic bile drainage can improve symptoms associated with insufficient liver and kidney function, coagulopathy, and jaundice. Surgical margin-negative (R0) resection, including major liver resection, is the most effective and potentially curative treatment for HC. If the tumor is not resected, then liver transplantation with adjuvant management can improve survival. We conducted a systematic review of developments in imaging studies and major surgical hepatectomy for HC with positive outcomes regarding quality of life.

Citing Articles

Molecular Biomarkers in Cholangiocarcinoma: Focus on Bile.

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Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies.

Tantau A, Mandrutiu A, Pop A, Zaharie R, Crisan D, Preda C World J Hepatol. 2021; 13(2):166-186.

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Recurrent Cholangiocarcinoma Presenting as Sister Mary Joseph Nodule After Liver Transplantation.

Muppidi V, Meegada S, Eason J, Nair S, Verma R Cureus. 2020; 12(11):e11673.

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Practical review for diagnosis and clinical management of perihilar cholangiocarcinoma.

Dondossola D, Ghidini M, Grossi F, Rossi G, Foschi D World J Gastroenterol. 2020; 26(25):3542-3561.

PMID: 32742125 PMC: 7366054. DOI: 10.3748/wjg.v26.i25.3542.

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