In Vivo Whole Animal Fluorescence Imaging of a Microparticle-based Oral Vaccine Containing (CuInSe(x)S(2-x))/ZnS Core/shell Quantum Dots

Overview

Journal Nano Lett

Publisher American Chemical Society

Specialty Biotechnology

Date 2013 Aug 7

PMID 23915166

Citations 11

Authors

Matthew G Panthani

Tarik A Khan

Dariya K Reid

Daniel J Hellebusch

Michael R Rasch

Jennifer A Maynard

Brian A Korgel

Affiliations

Soon will be listed here.

Abstract

Zinc sulfide-coated copper indium sulfur selenide (CuInSexS2-x/ZnS core/shell) nanocrystals were synthesized with size-tunable red to near-infrared (NIR) fluorescence with high quantum yield (40%) in water. These nanocrystals were tested as an imaging agent to track a microparticle-based oral vaccine administered to mice. Poly(lactic-co-glycolic acid) (PLGA) microparticle-encapsulated CuInSexSe2-x/ZnS quantum dots were orally administered to mice and were found to provide a distinct visible fluorescent marker in the gastrointestinal tract of living mice.

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