The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development

Overview

Journal Curr Colorectal Cancer Rep

Publisher Springer

Date 2013 Aug 6

PMID 23914149

Citations 6

Authors

Michelina Plateroti

Patricia Rosa de Araujo

Acarizia Eduardo da Silva

Luiz O F Penalva

Affiliations

Soon will be listed here.

Abstract

Aberrant gene expression is the cause and the consequence of tumorigenesis. A major component of gene expression is translation regulation; a process whose main players are RNA-binding-proteins (RBPs). More than 800 RBPs have been identified in the human genome and several of them have been shown to control gene networks associated with relevant cancer processes. A more systematic characterization of RBPs starts to reveal that similar to transcription factors, they can function as tumor suppressors or oncogenes. A relevant example is Musashi1 (Msi1), which is emerging as a critical regulator of tumorigenesis in multiple cancer types, including colon cancer. Msi1 is a stem marker in several tissues and is critical in maintaining the balance between self-renewal and differentiation. However, a boost in Msi1 expression can most likely lead cells towards an oncogenic pathway. In this article, we discuss the parallels between Msi1 function in normal renewal of intestinal epithelium and in colon cancer.

Citing Articles

Expression of Stem Cell Markers in High-LET Space Radiation-Induced Intestinal Tumors in Mouse Intestine.

Kwiatkowski E, Suman S, Kallakury B, Datta K, Fornace Jr A, Kumar S Cancers (Basel). 2023; 15(17).

PMID: 37686516 PMC: 10486545. DOI: 10.3390/cancers15174240.

Expression of Musashi-1 Increases in Bone Healing.

Padial-Molina M, Crespo-Lora V, Candido-Corral C, Martin-Morales N, Abril-Garcia D, Galindo-Moreno P Int J Mol Sci. 2021; 22(7).

PMID: 33810326 PMC: 8037090. DOI: 10.3390/ijms22073395.

Interplay among p21, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-Cre reserve intestinal stem cells after gamma radiation-induced injury.

Orzechowska E, Katano T, Bialkowska A, Yang V Sci Rep. 2020; 10(1):18300.

PMID: 33110120 PMC: 7591575. DOI: 10.1038/s41598-020-75171-w.

Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells.

Yi C, Li G, Ivanov D, Wang Z, Velasco M, Hernandez G RNA Biol. 2018; 15(11):1420-1432.

PMID: 30362859 PMC: 6284574. DOI: 10.1080/15476286.2018.1539607.

Stem Cells, Cancer, and MUSASHI in Blood and Guts.

Kharas M, Lengner C Trends Cancer. 2017; 3(5):347-356.

PMID: 28718412 PMC: 5546142. DOI: 10.1016/j.trecan.2017.03.007.

References

Okuno K, Ohta S, Kato H, Taga T, Sugita K, Takeuchi Y . Expression of neural stem cell markers in malignant rhabdoid tumor cell lines. Oncol Rep. 2010; 23(2):485-92. View

Goel A, Aggarwal B . Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer. 2010; 62(7):919-30. DOI: 10.1080/01635581.2010.509835. View

Fre S, Pallavi S, Huyghe M, Lae M, Janssen K, Robine S . Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A. 2009; 106(15):6309-14. PMC: 2649205. DOI: 10.1073/pnas.0900427106. View

Gotte M, Wolf M, Staebler A, Buchweitz O, Kelsch R, Schuring A . Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma. J Pathol. 2008; 215(3):317-29. DOI: 10.1002/path.2364. View

Moser A, Mattes E, Dove W, Lindstrom M, Haag J, Gould M . ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias. Proc Natl Acad Sci U S A. 1993; 90(19):8977-81. PMC: 47484. DOI: 10.1073/pnas.90.19.8977. View

Charlesworth A, Wilczynska A, Thampi P, Cox L, MacNicol A . Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation. EMBO J. 2006; 25(12):2792-801. PMC: 1500856. DOI: 10.1038/sj.emboj.7601159. View

Fujita M, Sato M, Nakamura M, Kudo K, Nagasaka T, Mizuno M . Multicentric atypical teratoid/rhabdoid tumors occurring in the eye and fourth ventricle of an infant: case report. J Neurosurg. 2005; 102(3 Suppl):299-302. DOI: 10.3171/ped.2005.102.3.0299. View

Okabe M, Imai T, Kurusu M, Hiromi Y, Okano H . Translational repression determines a neuronal potential in Drosophila asymmetric cell division. Nature. 2001; 411(6833):94-8. DOI: 10.1038/35075094. View

Strojnik T, Rosland G, Sakariassen P, Kavalar R, Lah T . Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival. Surg Neurol. 2007; 68(2):133-43. DOI: 10.1016/j.surneu.2006.10.050. View

10.

Asai R, Okano H, Yasugi S . Correlation between Musashi-1 and c-hairy-1 expression and cell proliferation activity in the developing intestine and stomach of both chicken and mouse. Dev Growth Differ. 2005; 47(8):501-10. DOI: 10.1111/j.1440-169X.2005.00825.x. View

11.

Sakatani T, Kaneda A, Iacobuzio-Donahue C, Carter M, de Boom Witzel S, Okano H . Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science. 2005; 307(5717):1976-8. DOI: 10.1126/science.1108080. View

12.

Sureban S, Murmu N, Rodriguez P, May R, Maheshwari R, Dieckgraefe B . Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation. Gastroenterology. 2007; 132(3):1055-65. DOI: 10.1053/j.gastro.2006.12.031. View

13.

Vega K, May R, Sureban S, Lightfoot S, Qu D, Reed A . Identification of the putative intestinal stem cell marker doublecortin and CaM kinase-like-1 in Barrett's esophagus and esophageal adenocarcinoma. J Gastroenterol Hepatol. 2011; 27(4):773-80. PMC: 3289765. DOI: 10.1111/j.1440-1746.2011.06928.x. View

14.

Thill M, Berna M, Grierson R, Reinhart I, Voelkel T, Piechaczek C . Expression of CD133 and other putative stem cell markers in uveal melanoma. Melanoma Res. 2011; 21(5):405-16. DOI: 10.1097/CMR.0b013e328348db10. View

15.

Spears E, Neufeld K . Novel double-negative feedback loop between adenomatous polyposis coli and Musashi1 in colon epithelia. J Biol Chem. 2011; 286(7):4946-50. PMC: 3037606. DOI: 10.1074/jbc.C110.205922. View

16.

Balaguer F, Link A, Lozano J, Cuatrecasas M, Nagasaka T, Boland C . Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis. Cancer Res. 2010; 70(16):6609-18. PMC: 2922409. DOI: 10.1158/0008-5472.CAN-10-0622. View

17.

Barker N, Bartfeld S, Clevers H . Tissue-resident adult stem cell populations of rapidly self-renewing organs. Cell Stem Cell. 2010; 7(6):656-70. DOI: 10.1016/j.stem.2010.11.016. View

18.

Yu T, Lan S, Wu B, Pan Q, Shi L, Huang K . Musashi1 and hairy and enhancer of split 1 high expression cells derived from embryonic stem cells enhance the repair of small-intestinal injury in the mouse. Dig Dis Sci. 2011; 56(5):1354-68. DOI: 10.1007/s10620-010-1441-9. View

19.

Seigel G, Hackam A, Ganguly A, Mandell L, Gonzalez-Fernandez F . Human embryonic and neuronal stem cell markers in retinoblastoma. Mol Vis. 2007; 13:823-32. PMC: 2768758. View

20.

Dimitriadis E, Trangas T, Milatos S, Foukas P, Gioulbasanis I, Courtis N . Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer. Int J Cancer. 2007; 121(3):486-94. DOI: 10.1002/ijc.22716. View