Electrografting of a Biodegradable Layer As a Primer Adhesion Coating Onto a Metallic Stent: in Vitro and in Vivo Evaluations

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2013 Aug 2

PMID 23904056

Citations 2

Authors

Gwenaelle Vergnol

Estelle Renard

Ferial Haroun

Patrice Guerin

Aymeric Seron

Christophe Bureau

Gervaise Loirand

Valerie Langlois

Affiliations

Soon will be listed here.

Abstract

Drug-eluting stents have been developed to reduce the risk of restenosis after angioplasty. To facilitate the adhesion of a poly(lactic acid) (PLA) overlayer loaded with rapamycin (20 wt%), a biodegradable macromonomer based on poly(lactic acid) (HEMA-PLA) was grafted onto the metallic stent by electrografting in a one-step reaction involving the immobilization of aryl diazonium onto the metal followed by an in situ surface electro-polymerization. The HEMA-PLA coating was chemically characterized. Mechanical performance during stent expansion was tested. Morphology examinations showed a strong adhesion of PLA topcoat in the presence of the electrografted layer. Biocompatibility and degradation of the coating were studied in vitro and in vivo in rabbit iliac arteries. These 28 days implantations resulted in a minimal inflammatory process with a partial degradation of the coating. These results suggest that this kind of anchoring of a biodegradable layer shows great potential for drug-eluting stents.

Citing Articles

Study of Mechanical Properties of PHBHV/Miscanthus Green Composites Using Combined Experimental and Micromechanical Approaches.

Lemaire T, Rodi E, Langlois V, Renard E, Sansalone V Polymers (Basel). 2021; 13(16).

PMID: 34451190 PMC: 8400164. DOI: 10.3390/polym13162650.

Osteoinductive activity of insulin-functionalized cell culture surfaces obtained using diazonium chemistry.

Mikulska A, Filipowska J, Osyczka A, Nowakowska M, Szczubialka K Front Chem. 2015; 2:117.

PMID: 25629028 PMC: 4292785. DOI: 10.3389/fchem.2014.00117.

References

Han Y, Wang S, Jing Q, Li Y, Liu H, Ma Y . Comparison of long-term efficacy of the paclitaxel-eluting stent versus the bare-metal stent for treatment of unprotected left main coronary artery disease. Am J Cardiol. 2009; 103(2):194-8. DOI: 10.1016/j.amjcard.2008.08.058. View

Palacin S, Bureau C, Charlier J, Deniau G, Mouanda B, Viel P . Molecule-to-metal bonds: electrografting polymers on conducting surfaces. Chemphyschem. 2004; 5(10):1468-81. DOI: 10.1002/cphc.200301202. View

Bertrand O, Sipehia R, Mongrain R, Rodes J, Tardif J, Bilodeau L . Biocompatibility aspects of new stent technology. J Am Coll Cardiol. 1998; 32(3):562-71. DOI: 10.1016/s0735-1097(98)00289-7. View

Zhang K, Liu T, Li J, Chen J, Wang J, Huang N . Surface modification of implanted cardiovascular metal stents: from antithrombosis and antirestenosis to endothelialization. J Biomed Mater Res A. 2013; 102(2):588-609. DOI: 10.1002/jbm.a.34714. View

Hanefeld P, Westedt U, Wombacher R, Kissel T, Schaper A, Wendorff J . Coating of poly(p-xylylene) by PLA-PEO-PLA triblock copolymers with excellent polymer-polymer adhesion for stent applications. Biomacromolecules. 2006; 7(7):2086-90. DOI: 10.1021/bm050642k. View

Papafaklis M, Chatzizisis Y, Naka K, Giannoglou G, Michalis L . Drug-eluting stent restenosis: effect of drug type, release kinetics, hemodynamics and coating strategy. Pharmacol Ther. 2012; 134(1):43-53. DOI: 10.1016/j.pharmthera.2011.12.006. View

Stefanadis C, Toutouzas K . Paclitaxel versus sirolimus: the battle is still ongoing. J Am Coll Cardiol. 2009; 53(8):665-6. DOI: 10.1016/j.jacc.2008.10.048. View

Rechavia E, Litvack F, Fishbien M, Nakamura M, Eigler N . Biocompatibility of polyurethane-coated stents: tissue and vascular aspects. Cathet Cardiovasc Diagn. 1998; 45(2):202-7. DOI: 10.1002/(sici)1097-0304(199810)45:2<202::aid-ccd20>3.0.co;2-l. View

Grube E, Schofer J, Hauptmann K, Nickenig G, Curzen N, Allocco D . A novel paclitaxel-eluting stent with an ultrathin abluminal biodegradable polymer 9-month outcomes with the JACTAX HD stent. JACC Cardiovasc Interv. 2010; 3(4):431-8. DOI: 10.1016/j.jcin.2009.12.015. View

10.

Pan C, Tang J, Weng Y, Wang J, Huang N . Preparation and characterization of rapamycin-loaded PLGA coating stent. J Mater Sci Mater Med. 2007; 18(11):2193-8. DOI: 10.1007/s10856-007-3075-9. View

11.

Mehilli J, Byrne R, Wieczorek A, Iijima R, Schulz S, Bruskina O . Randomized trial of three rapamycin-eluting stents with different coating strategies for the reduction of coronary restenosis. Eur Heart J. 2008; 29(16):1975-82. DOI: 10.1093/eurheartj/ehn253. View

12.

Okner R, Oron M, Tal N, Nyska A, Kumar N, Mandler D . Electrocoating of stainless steel coronary stents for extended release of paclitaxel. J Biomed Mater Res A. 2008; 88(2):427-36. DOI: 10.1002/jbm.a.31896. View

13.

Huang Y, Venkatraman S, Boey F, Lahti E, Umashankar P, Mohanty M . In vitro and in vivo performance of a dual drug-eluting stent (DDES). Biomaterials. 2010; 31(15):4382-91. DOI: 10.1016/j.biomaterials.2010.01.147. View

14.

Byrne R, Kastrati A, Kufner S, Massberg S, Birkmeier K, Laugwitz K . Randomized, non-inferiority trial of three limus agent-eluting stents with different polymer coatings: the Intracoronary Stenting and Angiographic Results: Test Efficacy of 3 Limus-Eluting Stents (ISAR-TEST-4) Trial. Eur Heart J. 2009; 30(20):2441-9. DOI: 10.1093/eurheartj/ehp352. View

15.

Kastrati A, Mehilli J, Pache J, Kaiser C, Valgimigli M, Kelbaek H . Analysis of 14 trials comparing sirolimus-eluting stents with bare-metal stents. N Engl J Med. 2007; 356(10):1030-9. DOI: 10.1056/NEJMoa067484. View

16.

Marx S, Marks A . Bench to bedside: the development of rapamycin and its application to stent restenosis. Circulation. 2001; 104(8):852-5. DOI: 10.1161/01.cir.104.8.852. View

17.

Cho H, Han D, Matsumura K, Tsutsumi S, Hyon S . The behavior of vascular smooth muscle cells and platelets onto epigallocatechin gallate-releasing poly(l-lactide-co-epsilon-caprolactone) as stent-coating materials. Biomaterials. 2007; 29(7):884-93. DOI: 10.1016/j.biomaterials.2007.10.052. View

18.

De Scheerder I, Wilczek K, Verbeken E, Vandorpe J, Lan P, Schacht E . Biocompatibility of polymer-coated oversized metallic stents implanted in normal porcine coronary arteries. Atherosclerosis. 1995; 114(1):105-14. DOI: 10.1016/0021-9150(94)05472-u. View

19.

Mainil-Varlet P, Curtis R, Gogolewski S . Effect of in vivo and in vitro degradation on molecular and mechanical properties of various low-molecular-weight polylactides. J Biomed Mater Res. 1997; 36(3):360-80. DOI: 10.1002/(sici)1097-4636(19970905)36:3<360::aid-jbm11>3.0.co;2-i. View

20.

Xi T, Gao R, Xu B, Chen L, Luo T, Liu J . In vitro and in vivo changes to PLGA/sirolimus coating on drug eluting stents. Biomaterials. 2010; 31(19):5151-8. DOI: 10.1016/j.biomaterials.2010.02.003. View