Computed Diffusion-weighted Imaging Using 3-T Magnetic Resonance Imaging for Prostate Cancer Diagnosis

Overview

Journal Eur Radiol

Specialty Radiology

Date 2013 Jul 25

PMID 23881300

Citations 31

Authors

Yoshiko Ueno

Satoru Takahashi

Kazuhiro Kitajima

Tokunori Kimura

Ikuo Aoki

Fumi Kawakami

Hideaki Miyake

Yoshiharu Ohno

Kazuro Sugimura

Affiliations

Soon will be listed here.

Abstract

Objective: To assess the efficacy of computed diffusion-weighted images (cDWIs) of b = 2000 s/mm(2) (cDWI2000) generated from DWIs of b = 0 and 1000 for prostate cancer (PCa) diagnosis in comparison with that of measured original DWIs of b = 1000 (mDWI1000) and b = 2000(mDWI2000) using 3-T MRI.

Methods: Eighty patients who underwent a preoperative MRI examination, including T2WI and DWI (b = 0, 1000, 2000 s/mm(2)), were enrolled in this study. Four combinations of images, protocol A (T2WI alone), B (T2WI + mDWI1000), C (T2WI + mDWI2000) and D (T2WI + cDWI2000), were assessed for their diagnostic capability. Areas under the receiver operating characteristic curve (Az) and diagnostic performance were evaluated, as well as contrast ratios (CR) between cancerous and non-cancerous lesions for each DWI.

Results: The highest CR was obtained with cDWI2000 (0.29 ± 0.16). Sensitivity, specificity, accuracy, and Az of the protocols were: A: 66.3 %, 59.4 %, 63.0 %, 0.67; B: 82.6 %, 62.0 %, 72.5 %, 0.80; C: 84.1 %, 66.5 %, 75.5 %, 0.86; D: 83.2 %, 70.0 %, 76.6 %, and 0.84, respectively The specificities and accuracies of protocol C and D were significantly higher than those of protocol B (P < 0.05).

Conclusion: cDWI2000 appears to be more effective than mDWI1000, and at least as effective as mDWI2000 for PCa diagnosis.

Citing Articles

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Enhanced Image Processing Using Complex Averaging in Diffusion-Weighted Imaging of the Prostate: The Impact on Image Quality and Lesion Detectability.

Werner S, Zinsser D, Esser M, Nickel D, Nikolaou K, Othman A Diagnostics (Basel). 2023; 13(14).

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Evaluating Biliary Malignancy with Measured and Calculated Ultra-high b-value Diffusion-weighted MR Imaging at 3T.

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Do the variations in ROI placement technique have influence for prostate ADC measurements?.

Ueno Y, Tamada T, Sofue K, Urase Y, Hinata N, Fujisawa M Acta Radiol Open. 2022; 11(3):20584601221086500.

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Diffusion and quantification of diffusion of prostate cancer.

Ueno Y, Tamada T, Sofue K, Murakami T Br J Radiol. 2021; 95(1131):20210653.

PMID: 34538094 PMC: 8978232. DOI: 10.1259/bjr.20210653.

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