Evaluation of Association Between Airway Hyperresponsiveness, Asthma Control Test, and Asthma Therapy Assessment Questionnaire in Asthmatic Children

Overview

Journal Multidiscip Respir Med

Specialty Pulmonary Medicine

Date 2013 Jul 25

PMID 23879928

Citations 4

Authors

Daniele Rapino

Marina Attanasi

Nicola P Consilvio

Alessandra Scaparrotta

Anna Cingolani

Marzia Cerasa

Angelika Mohn

Sabrina Di Pillo

Francesco Chiarelli

Affiliations

Soon will be listed here.

Abstract

Background: Achieving asthma control is a major challenge in children, otherwise symptoms perception remain poor especially at this age. The aim of this study is to evaluate the relationship between Asthma Control Test (ACTTM), Asthma Therapy Assessment Questionnaire (ATAQTM) and exercise-induced bronchospasm (EIB).

Methods: We studied 80 asthmatic children. Airways hyperresponsiveness (AHR) was assessed by exercise-induced bronchospasm (Balke Protocol). Asthma control was evaluated using two questionnaires in all subjects: ACT (composed by Childhood-ACT and ACT) and ATAQ. In addition the use of short acting beta 2 agonist agents (SABAs) was assessed for each patient. Non-parametric variables were compared by Chi Square Test. Binomial logistic regression was performed to estimate the two questionnaires Odds Ratio (OR) in finding AHR.

Results: We have found that ATAQ has a sensitivity and a specificity of 0.72 and 0.45 respectively; instead, ACT has a sensitivity and a specificity of 0.5 and 0.39 respectively in evaluating AHR. Patients with uncontrolled asthma according to ATAQ revealed a significant higher percentage of AHR compared with ACT (72% vs 50%, p < 0.01).Confirming this finding, patients declaring uncontrolled asthma to ATAQ have a significantly higher percentage (34%) of frequent SABAs use than the group with uncontrolled asthma to ACT (21%) (p <0.01).Binomial logistic regression shows how a test revealing uncontrolled asthma is associated with the increasing odds of having AHR according to ATAQ (OR = 3.8, p = 0.05), not to ACT (OR = 0.2, p = 0.1).

Conclusions: Our results show that ATAQ reflects AHR and asthma control better than ACT. Children with uncontrolled asthma according to ATAQ have higher odds of having AHR and use of rescue medications (SABAs) compared to patients declaring uncontrolled asthma according to ACT. However both questionnaires are not sufficient alone to fully evaluate asthma control in children and it is always necessary to perform functional tests and investigate patients lifestyle, drug use and other important data that a simple questionnaire is not able to point out.

Citing Articles

eHealth Technologies for Monitoring Pediatric Asthma at Home: Scoping Review.

van der Kamp M, Hengeveld V, Brusse-Keizer M, Thio B, Tabak M J Med Internet Res. 2023; 25:e45896.

PMID: 37477966 PMC: 10403763. DOI: 10.2196/45896.

Validity of the Childhood Asthma Control Test in diverse populations: A systematic review.

Chu F, Kappel N, Akel M, Press V, Alexander J, Volerman A Pediatr Pulmonol. 2023; 58(5):1322-1336.

PMID: 36718492 PMC: 10121871. DOI: 10.1002/ppul.26342.

Assessing Exercise-Induced Bronchoconstriction in Children; The Need for Testing.

Lammers N, van Hoesel M, Kamphuis M, Brusse-Keizer M, van der Palen J, Visser R Front Pediatr. 2019; 7:157.

PMID: 31106184 PMC: 6498950. DOI: 10.3389/fped.2019.00157.

Reported Exercise-Related Respiratory Symptoms and Exercise-Induced Bronchoconstriction in Asthmatic Children.

Inci D, Guggenheim R, Altintas D, Wildhaber J, Moeller A J Clin Med Res. 2017; 9(5):410-415.

PMID: 28392861 PMC: 5380174. DOI: 10.14740/jocmr2935w.

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