Nanoparticle-programmed Self-destructive Neural Stem Cells for Glioblastoma Targeting and Therapy

Overview

Journal Small

Date 2013 Jul 23

PMID 23873826

Citations 42

Authors

Yu Cheng

Ramin Morshed

Shih-Hsun Cheng

Alex Tobias

Brenda Auffinger

Derek A Wainwright

Lingjiao Zhang

Catherine Yunis

Yu Han

Chin-Tu Chen

Leu-Wei Lo

Karen S Aboody

Atique U Ahmed

Maciej S Lesniak

Affiliations

Soon will be listed here.

Abstract

A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.

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