Role and Mechanism of Neural Stem Cells of the Subventricular Zone in Glioblastoma

Overview

Journal World J Stem Cells

Publisher Baishideng Publishing Group

Date 2021 Aug 9

PMID 34367482

Citations 16

Authors

Gui-Long Zhang

Chuan-Fang Wang

Cheng Qian

Yun-Xiang Ji

Ye-Zhong Wang

Affiliations

Soon will be listed here.

Abstract

Glioblastoma multiforme (GBM), the most frequently occurring malignant brain tumor in adults, remains mostly untreatable. Because of the heterogeneity of invasive gliomas and drug resistance associated with the tumor microenvironment, the prognosis is poor, and the survival rate of patients is low. Communication between GBMs and non-glioma cells in the tumor microenvironment plays a vital role in tumor growth and recurrence. Emerging data have suggested that neural stem cells (NSCs) in the subventricular zone (SVZ) are the cells-of-origin of gliomas, and SVZ NSC involvement is associated with the progression and recurrence of GBM. This review highlights the interaction between SVZ NSCs and gliomas, summarizes current findings on the crosstalk between gliomas and other non-glioma cells, and describes the links between SVZ NSCs and gliomas. We also discuss the role and mechanism of SVZ NSCs in glioblastoma, as well as the interventions targeting the SVZ and their therapeutic implications in glioblastoma. Taken together, understanding the biological mechanism of glioma-NSC interactions can lead to new therapeutic strategies for GBM.

Citing Articles

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Deciphering the role of transcription factors in glioblastoma cancer stem cells.

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A Novel Molecular Classification Method for Glioblastoma Based on Tumor Cell Differentiation Trajectories.

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References

Matarredona E, Pastor A . Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications. Front Oncol. 2019; 9:779. PMC: 6710355. DOI: 10.3389/fonc.2019.00779. View

Liu H, Wang Y, Belz T, Bock D, Takacs A, Radlwimmer B . The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev. 2010; 24(7):683-95. PMC: 2849125. DOI: 10.1101/gad.560310. View

Spencer D, Yu D, Morshed R, Li G, Pituch K, Gao D . Pharmacologic modulation of nasal epithelium augments neural stem cell targeting of glioblastoma. Theranostics. 2019; 9(7):2071-2083. PMC: 6485287. DOI: 10.7150/thno.29581. View

Florek J, Caillard R, Kleitz F . Evaluation of mesoporous silica nanoparticles for oral drug delivery - current status and perspective of MSNs drug carriers. Nanoscale. 2017; 9(40):15252-15277. DOI: 10.1039/c7nr05762h. View

Teng J, Hejazi S, Badr C, Tannous B . Systemic anticancer neural stem cells in combination with a cardiac glycoside for glioblastoma therapy. Stem Cells. 2014; 32(8):2021-32. PMC: 4454401. DOI: 10.1002/stem.1727. View

Alderton G . Tumorigenesis: the origins of glioma. Nat Rev Cancer. 2011; 11(9):627. DOI: 10.1038/nrc3129. View

Bulstrode H, Johnstone E, Marques-Torrejon M, Ferguson K, Bressan R, Blin C . Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators. Genes Dev. 2017; 31(8):757-773. PMC: 5435889. DOI: 10.1101/gad.293027.116. View

Kwan K, Schneider J, Patel N, Boockvar J . Tracing the Origin of Glioblastoma: Subventricular Zone Neural Stem Cells. Neurosurgery. 2018; 84(1):E15-E16. DOI: 10.1093/neuros/nyy512. View

Walton N, Snyder G, Park D, Kobeissy F, Scheffler B, Steindler D . Gliotypic neural stem cells transiently adopt tumorigenic properties during normal differentiation. Stem Cells. 2008; 27(2):280-9. PMC: 4425277. DOI: 10.1634/stemcells.2008-0842. View

10.

Ortega J, Sirois C, Memi F, Glidden N, Zecevic N . Oxygen Levels Regulate the Development of Human Cortical Radial Glia Cells. Cereb Cortex. 2016; 27(7):3736-3751. PMC: 6075453. DOI: 10.1093/cercor/bhw194. View

11.

Wang D, Starr R, Chang W, Aguilar B, Alizadeh D, Wright S . Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma. Sci Transl Med. 2020; 12(533). PMC: 7500824. DOI: 10.1126/scitranslmed.aaw2672. View

12.

Kim C, Ahmed A, Auffinger B, Ulasov I, Tobias A, Moon K . N-acetylcysteine amide augments the therapeutic effect of neural stem cell-based antiglioma oncolytic virotherapy. Mol Ther. 2013; 21(11):2063-73. PMC: 3831038. DOI: 10.1038/mt.2013.179. View

13.

Walzlein J, Synowitz M, Engels B, Markovic D, Gabrusiewicz K, Nikolaev E . The antitumorigenic response of neural precursors depends on subventricular proliferation and age. Stem Cells. 2008; 26(11):2945-54. DOI: 10.1634/stemcells.2008-0307. View

14.

Budi Hartono S, Phuoc N, Yu M, Jia Z, Monteiro M, Qiao S . Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery. J Mater Chem B. 2020; 2(6):718-726. DOI: 10.1039/c3tb21015d. View

15.

Chen L, Chaichana K, Kleinberg L, Ye X, Quinones-Hinojosa A, Redmond K . Glioblastoma recurrence patterns near neural stem cell regions. Radiother Oncol. 2015; 116(2):294-300. PMC: 4857206. DOI: 10.1016/j.radonc.2015.07.032. View

16.

Yamaki T, Shibahra I, Matsuda K, Kanemura Y, Konta T, Kanamori M . Relationships between recurrence patterns and subventricular zone involvement or CD133 expression in glioblastoma. J Neurooncol. 2020; 146(3):489-499. DOI: 10.1007/s11060-019-03381-y. View

17.

Nakano I, Garnier D, Minata M, Rak J . Extracellular vesicles in the biology of brain tumour stem cells--Implications for inter-cellular communication, therapy and biomarker development. Semin Cell Dev Biol. 2015; 40:17-26. DOI: 10.1016/j.semcdb.2015.02.011. View

18.

Xia X, Wang Y, Huang Y, Zhang H, Lu H, Zheng J . Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents. Prog Neurobiol. 2019; 183:101694. PMC: 7323939. DOI: 10.1016/j.pneurobio.2019.101694. View

19.

Aboody K, Brown A, Rainov N, Bower K, Liu S, Yang W . Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci U S A. 2000; 97(23):12846-51. PMC: 18852. DOI: 10.1073/pnas.97.23.12846. View

20.

Cheng S, Yu D, Tsai H, Morshed R, Kanojia D, Lo L . Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma. J Nucl Med. 2015; 57(2):279-84. PMC: 5831675. DOI: 10.2967/jnumed.115.163006. View