Lithothamnion Muelleri Controls Inflammatory Responses, Target Organ Injury and Lethality Associated with Graft-versus-host Disease in Mice

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2013 Jul 23

PMID 23873335

Citations 9

Authors

Barbara M Rezende

Priscila T T Bernardes

Carolina B Resende

Rosa M E Arantes

Danielle G Souza

Fernao C Braga

Marina G M Castor

Mauro M Teixeira

Vanessa Pinho

Affiliations

Soon will be listed here.

Abstract

Lithothamnion muelleri (Hapalidiaceae) is a marine red alga, which is a member of a group of algae with anti-inflammatory, antitumor, and immunomodulatory properties. The present study evaluated the effects of treatment with Lithothamnion muelleri extract (LM) in a model of acute graft-versus-host disease (GVHD), using a model of adoptive splenocyte transfer from C57BL/6 donors into B6D2F1 recipient mice. Mice treated with LM showed reduced clinical signs of disease and mortality when compared with untreated mice. LM-treated mice had reduced tissue injury, less bacterial translocation, and decreased levels of proinflammatory cytokines and chemokines (interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5)). The polysaccharide-rich fraction derived from LM could inhibit leukocyte rolling and adhesion in intestinal venules, as assessed by intravital microscopy. LM treatment did not impair the beneficial effects of graft-versus-leukaemia (GVL). Altogether, our studies suggest that treatment with Lithothamnion muelleri has a potential therapeutic application in GVHD treatment.

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