Antagonistic Regulation by the Transcription Factors C/EBPα and MITF Specifies Basophil and Mast Cell Fates

Overview

Journal Immunity

Publisher Cell Press

Specialty Allergy & Immunology

Date 2013 Jul 23

PMID 23871207

Citations 77

Authors

Xiaopeng Qi

Jessie Hong

Lee Chaves

Yonghua Zhuang

Yuhong Chen

Demin Wang

Jacob Chabon

Brian Graham

Keitaro Ohmori

Yapeng Li

Hua Huang

Affiliations

Soon will be listed here.

Abstract

It remains unclear whether basophils and mast cells are derived from a common progenitor. Furthermore, how basophil versus mast cell fate is specified has not been investigated. Here, we have identified a population of granulocyte-macrophage progenitors (GMPs) that were highly enriched in the capacity to differentiate into basophils and mast cells while retaining a limited capacity to differentiate into myeloid cells. We have designated these progenitor cells "pre-basophil and mast cell progenitors" (pre-BMPs). STAT5 signaling was required for the differentiation of pre-BMPs into both basophils and mast cells and was critical for inducing two downstream molecules: C/EBPα and MITF. We have identified C/EBPα as the critical basophil transcription factor for specifying basophil cell fate and MITF as the crucial transcription factor for specifying mast cell fate. C/EBPα and MITF silenced each other's transcription in a directly antagonistic fashion. Our study reveals how basophil and mast cell fate is specified.

Citing Articles

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