GATA-1 As a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1low Mouse Mutant

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2003 Feb 5

PMID 12566412

Citations 92

Authors

Anna Rita Migliaccio

Rosa Alba Rana

Massimo Sanchez

Rodolfo Lorenzini

Lucia Centurione

Lucia Bianchi

Alessandro Maria Vannucchi

Giovanni Migliaccio

Stuart H Orkin

Affiliations

Soon will be listed here.

Abstract

Here it is shown that the phenotype of adult mice lacking the first enhancer (DNA hypersensitive site I) and the distal promoter of the GATA-1 gene (neo Delta HS or GATA-1(low) mutants) reveals defects in mast cell development. These include the presence of morphologically abnormal alcian blue(+) mast cells and apoptotic metachromatic(-) mast cell precursors in connective tissues and peritoneal lavage and numerous (60-70% of all the progenitors) "unique" trilineage cells committed to erythroid, megakaryocytic, and mast pathways in the bone marrow and spleen. These abnormalities, which were mirrored by impaired mast differentiation in vitro, were reversed by retroviral-mediated expression of GATA-1 cDNA. These data indicate an essential role for GATA-1 in mast cell differentiation.

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