Quantitative Myocardial Perfusion Imaging by Cardiovascular Magnetic Resonance and Positron Emission Tomography

Overview

Journal J Nucl Cardiol

Specialty Cardiology & Vascular Diseases

Date 2013 Jul 23

PMID 23868071

Citations 10

Authors

K Bratis

I Mahmoud

A Chiribiri

E Nagel

Affiliations

Soon will be listed here.

Abstract

Recent studies have demonstrated that a detailed knowledge of the extent of angiographic coronary artery disease (CAD) is not a prerequisite for clinical decision making, and the clinical management of patients with CAD is more and more focused towards the identification of myocardial ischemia and the quantification of ischemic burden. In this view, non-invasive assessment of ischemia and in particular stress imaging techniques are emerging as preferred and non-invasive options. A quantitative assessment of regional myocardial perfusion can provide an objective estimate of the severity of myocardial injury and may help clinicians to discriminate regions of the heart that are at increased risk for myocardial infarction. Positron emission tomography (PET) has established itself as the reference standard for myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) quantification. Cardiac magnetic resonance (CMR) is increasingly used to measure MBF and MPR by means of first-pass signals, with a well-defined diagnostic performance and prognostic value. The aim of this article is to review the currently available evidence on the use of both PET and CMR for quantification of MPR, with particular attention to the studies that directly compared these two diagnostic methods.

Citing Articles

MRI of cardiac involvement in COVID-19.

Rafiee M, Friedrich M Br J Radiol. 2024; 97(1160):1367-1377.

PMID: 38656976 PMC: 11256941. DOI: 10.1093/bjr/tqae086.

Pixel-wise assessment of cardiovascular magnetic resonance first-pass perfusion using a cardiac phantom mimicking transmural myocardial perfusion gradients.

Milidonis X, Nazir M, Schneider T, Capstick M, Drost S, Kok G Magn Reson Med. 2020; 84(5):2871-2884.

PMID: 32426854 PMC: 7611223. DOI: 10.1002/mrm.28296.

Simultaneous N-Ammonia and gadolinium first-pass myocardial perfusion with quantitative hybrid PET-MR imaging: a phantom and clinical feasibility study.

Nazir M, Gould S, Milidonis X, Reyes E, Ismail T, Neji R Eur J Hybrid Imaging. 2019; 3(1):15.

PMID: 31544170 PMC: 6718374. DOI: 10.1186/s41824-019-0062-6.

Limitations of Quantitative Blush Evaluator (QuBE) as myocardial perfusion assessment method on digital coronary angiograms.

Prasetya H, Beijk M, Konduri P, Epema T, Hirsch A, van der Harst P J Clin Transl Res. 2019; 3(Suppl 2):394-400.

PMID: 30873487 PMC: 6412616.

Hybrid positron emission tomography-magnetic resonance of the heart: current state of the art and future applications.

Nazir M, Ismail T, Reyes E, Chiribiri A, Kaufmann P, Plein S Eur Heart J Cardiovasc Imaging. 2018; 19(9):962-974.

PMID: 30010838 PMC: 6102801. DOI: 10.1093/ehjci/jey090.

References

Gistri R, Cecchi F, Choudhury L, Montereggi A, Sorace O, Salvadori P . Effect of verapamil on absolute myocardial blood flow in hypertrophic cardiomyopathy. Am J Cardiol. 1994; 74(4):363-8. DOI: 10.1016/0002-9149(94)90404-9. View

Nagamachi S, Czernin J, Kim A, Sun K, Bottcher M, Phelps M . Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET. J Nucl Med. 1996; 37(10):1626-31. View

Tonino P, De Bruyne B, Pijls N, Siebert U, Ikeno F, van t Veer M . Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009; 360(3):213-24. DOI: 10.1056/NEJMoa0807611. View

Kaufmann P, Gnecchi-Ruscone T, Di Terlizzi M, Schafers K, Luscher T, Camici P . Coronary heart disease in smokers: vitamin C restores coronary microcirculatory function. Circulation. 2000; 102(11):1233-8. DOI: 10.1161/01.cir.102.11.1233. View

Gebker R, Schwitter J, Fleck E, Nagel E . How we perform myocardial perfusion with cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2007; 9(3):539-47. DOI: 10.1080/10976640600897286. View

Pack N, DiBella E, Rust T, Kadrmas D, McGann C, Butterfield R . Estimating myocardial perfusion from dynamic contrast-enhanced CMR with a model-independent deconvolution method. J Cardiovasc Magn Reson. 2008; 10:52. PMC: 2596132. DOI: 10.1186/1532-429X-10-52. View

Shin T, Hu H, Pohost G, Nayak K . Three dimensional first-pass myocardial perfusion imaging at 3T: feasibility study. J Cardiovasc Magn Reson. 2008; 10:57. PMC: 2614420. DOI: 10.1186/1532-429X-10-57. View

Al-Saadi N, Gross M, Bornstedt A, Schnackenburg B, Klein C, Fleck E . [Comparison of various parameters for determining an index of myocardial perfusion reserve in detecting coronary stenosis with cardiovascular magnetic resonance tomography]. Z Kardiol. 2002; 90(11):824-34. DOI: 10.1007/s003920170081. View

Herzog B, Husmann L, Valenta I, Gaemperli O, Siegrist P, Tay F . Long-term prognostic value of 13N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol. 2009; 54(2):150-6. DOI: 10.1016/j.jacc.2009.02.069. View

10.

Dorbala S, Di Carli M, Beanlands R, Merhige M, Williams B, Veledar E . Prognostic value of stress myocardial perfusion positron emission tomography: results from a multicenter observational registry. J Am Coll Cardiol. 2012; 61(2):176-84. PMC: 3549438. DOI: 10.1016/j.jacc.2012.09.043. View

11.

Cecchi F, Olivotto I, Gistri R, Lorenzoni R, Chiriatti G, Camici P . Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy. N Engl J Med. 2003; 349(11):1027-35. DOI: 10.1056/NEJMoa025050. View

12.

Ibrahim T, Nekolla S, Schreiber K, Odaka K, Volz S, Mehilli J . Assessment of coronary flow reserve: comparison between contrast-enhanced magnetic resonance imaging and positron emission tomography. J Am Coll Cardiol. 2002; 39(5):864-70. DOI: 10.1016/s0735-1097(01)01829-0. View

13.

Muehling O, Jerosch-Herold M, Panse P, Zenovich A, Wilson B, Wilson R . Regional heterogeneity of myocardial perfusion in healthy human myocardium: assessment with magnetic resonance perfusion imaging. J Cardiovasc Magn Reson. 2004; 6(2):499-507. DOI: 10.1081/jcmr-120030570. View

14.

Hsu L, Groves D, Aletras A, Kellman P, Arai A . A quantitative pixel-wise measurement of myocardial blood flow by contrast-enhanced first-pass CMR perfusion imaging: microsphere validation in dogs and feasibility study in humans. JACC Cardiovasc Imaging. 2012; 5(2):154-66. PMC: 3460374. DOI: 10.1016/j.jcmg.2011.07.013. View

15.

Morton G, Chiribiri A, Ishida M, Hussain S, Schuster A, Indermuehle A . Quantification of absolute myocardial perfusion in patients with coronary artery disease: comparison between cardiovascular magnetic resonance and positron emission tomography. J Am Coll Cardiol. 2012; 60(16):1546-55. PMC: 7611225. DOI: 10.1016/j.jacc.2012.05.052. View

16.

Canetti M, Akhter M, Lerman A, Karaalp I, Zell J, Singh H . Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy. Am J Cardiol. 2003; 92(10):1246-9. DOI: 10.1016/j.amjcard.2003.08.002. View

17.

Dayanikli F, Grambow D, Muzik O, Mosca L, Rubenfire M, Schwaiger M . Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography. Circulation. 1994; 90(2):808-17. DOI: 10.1161/01.cir.90.2.808. View

18.

Garcia E . Physical attributes, limitations, and future potential for PET and SPECT. J Nucl Cardiol. 2011; 19 Suppl 1:S19-29. DOI: 10.1007/s12350-011-9488-3. View

19.

Camici P, Chiriatti G, Lorenzoni R, Bellina R, Gistri R, Italiani G . Coronary vasodilation is impaired in both hypertrophied and nonhypertrophied myocardium of patients with hypertrophic cardiomyopathy: a study with nitrogen-13 ammonia and positron emission tomography. J Am Coll Cardiol. 1991; 17(4):879-86. DOI: 10.1016/0735-1097(91)90869-b. View

20.

CULLEN J, Horsfield M, Reek C, Cherryman G, Barnett D, Samani N . A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging. J Am Coll Cardiol. 1999; 33(5):1386-94. DOI: 10.1016/s0735-1097(99)00004-2. View