Comparison of α2-macroglobulin Synthesis by Juvenile Vs. Mature Rats After Identical Inflammatory Stimulation

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 2013 Jul 17

PMID 23856939

Citations 3

Authors

Takashi Kuribayashi

Tetsuro Seita

Katsuhito Kawato

Shunsuke Yamazaki

Shizuo Yamamoto

Affiliations

Soon will be listed here.

Abstract

Synthesis of α2-macoglobulin (α2M) by 3-week-old juvenile rats was compared to that of mature 7- and 11-week-old rats. Serum concentrations of α2M, interleukin (IL)-6- and cytokine-induced neutrophil chemoattractant (CINC)-1 were measured by enzyme-linked immunosorbent assay. The area under the concentration vs. time curve (AUC) for α2M was significantly different among the three groups. The synthesis of α2M increased in an age-dependent manner. No significant difference was observed for the AUC of IL-6, but that of CINC-1 in 3-week-old rats was significantly lower than that in 7- or 11-week-old rats. These results suggest that synthesis of α2M was increased in mature compared to juvenile rats, possibly due to differences in liver function. The maximum concentration of CINC-1 in 3-week-old rats was observed 6 h after turpentine oil injection. The serum concentrations of IL-6 and CINC-1 increased more quickly in juvenile rats than in mature rats after inflammatory stimulation.

Citing Articles

Elimination half-lives of interleukin-6 and cytokine-induced neutrophil chemoattractant-1 synthesized in response to inflammatory stimulation in rats.

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Effect of Immunosuppressive Therapy on Proteinogram in Rats.

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Elimination Half-Lives of Acute Phase Proteins in Rats and Beagle Dogs During Acute Inflammation.

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