Mortality Associated with Influenza in Tropics, State of São Paulo, Brazil, from 2002 to 2011: the Pre-pandemic, Pandemic, and Post-pandemic Periods

Overview

Journal Influenza Res Treat

Date 2013 Jul 12

PMID 23844285

Citations 13

Authors

Andre Ricardo Ribas Freitas

Priscila M S Bergamo Francisco

Maria Rita Donalisio

Affiliations

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Abstract

The impact of the seasonal influenza and 2009 AH1N1 pandemic influenza on mortality is not yet completely understood, particularly in tropical and subtropical countries. The trends of influenza related mortality rate in different age groups and different outcomes on a area in tropical and subtropical climate with more than 41 million people (State of São Paulo, Brazil), were studied from 2002 to 2011 were studied. Serfling-type regression analysis was performed using weekly mortality registries and virological data obtained from sentinel surveillance. The prepandemic years presented a well-defined seasonality during winter and a clear relationship between activity of AH3N2 and increase of mortality in all ages, especially in individuals older than 60 years. The mortality due to pneumonia and influenza and respiratory causes associated with 2009 pandemic influenza in the age groups 0-4 years and older than 60 was lower than the previous years. Among people aged 5-19 and 20-59 years the mortality was 2.6 and 4.4 times higher than that in previous periods, respectively. The mortality in all ages was higher than the average of the previous years but was equal mortality in epidemics of AH3N2. The 2009 pandemic influenza mortality showed significant differences compared to other years, especially considering the age groups most affected.

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References

Madjid M, Naghavi M, Litovsky S, Casscells S . Influenza and cardiovascular disease: a new opportunity for prevention and the need for further studies. Circulation. 2003; 108(22):2730-6. DOI: 10.1161/01.CIR.0000102380.47012.92. View

Serfling R . Methods for current statistical analysis of excess pneumonia-influenza deaths. Public Health Rep (1896). 2009; 78(6):494-506. PMC: 1915276. View

Simonsen L, Clarke M, Williamson G, Stroup D, Arden N, Schonberger L . The impact of influenza epidemics on mortality: introducing a severity index. Am J Public Health. 1998; 87(12):1944-50. PMC: 1381234. DOI: 10.2105/ajph.87.12.1944. View

Yang L, Chan K, Cowling B, Chiu S, Chan K, Peiris J . Excess mortality associated with the 2009 pandemic of influenza A(H1N1) in Hong Kong. Epidemiol Infect. 2011; 140(9):1542-50. DOI: 10.1017/S0950268811002238. View

van den Wijngaard C, van Asten L, Koopmans M, van Pelt W, Nagelkerke N, Wielders C . Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children. PLoS One. 2012; 7(2):e31197. PMC: 3272034. DOI: 10.1371/journal.pone.0031197. View

Shrestha S, Swerdlow D, Borse R, Prabhu V, Finelli L, Atkins C . Estimating the burden of 2009 pandemic influenza A (H1N1) in the United States (April 2009-April 2010). Clin Infect Dis. 2011; 52 Suppl 1:S75-82. DOI: 10.1093/cid/ciq012. View

Redlberger-Fritz M, Aberle J, Popow-Kraupp T, Kundi M . Attributable deaths due to influenza: a comparative study of seasonal and pandemic influenza. Eur J Epidemiol. 2012; 27(7):567-75. DOI: 10.1007/s10654-012-9701-y. View

Lemaitre M, Carrat F, Rey G, Miller M, Simonsen L, Viboud C . Mortality burden of the 2009 A/H1N1 influenza pandemic in France: comparison to seasonal influenza and the A/H3N2 pandemic. PLoS One. 2012; 7(9):e45051. PMC: 3447811. DOI: 10.1371/journal.pone.0045051. View

Mytton O, Rutter P, Donaldson L . Influenza A(H1N1)pdm09 in England, 2009 to 2011: a greater burden of severe illness in the year after the pandemic than in the pandemic year. Euro Surveill. 2012; 17(14). View

10.

Collins S, Lehmann J . Trends and epidemics of influenza and pneumonia: 1918-1951. Public Health Rep (1896). 1951; 66(46):1487-1516. PMC: 2030670. View

11.

Tamerius J, Nelson M, Zhou S, Viboud C, Miller M, Alonso W . Global influenza seasonality: reconciling patterns across temperate and tropical regions. Environ Health Perspect. 2010; 119(4):439-45. PMC: 3080923. DOI: 10.1289/ehp.1002383. View

12.

Charu V, Chowell G, Mejia L, Echevarria-Zuno S, Borja-Aburto V, Simonsen L . Mortality burden of the A/H1N1 pandemic in Mexico: a comparison of deaths and years of life lost to seasonal influenza. Clin Infect Dis. 2011; 53(10):985-93. PMC: 3202315. DOI: 10.1093/cid/cir644. View

13.

Chow A, Ma S, Ling A, Chew S . Influenza-associated deaths in tropical Singapore. Emerg Infect Dis. 2006; 12(1):114-21. PMC: 3293465. DOI: 10.3201/eid1201.050826. View

14.

Nicoll A, Ciancio B, Lopez Chavarrias V, Molbak K, Pebody R, Pedzinski B . Influenza-related deaths--available methods for estimating numbers and detecting patterns for seasonal and pandemic influenza in Europe. Euro Surveill. 2012; 17(18). DOI: 10.2807/ese.17.18.20162-en. View

15.

Schuck-Paim C, Viboud C, Simonsen L, Miller M, Moura F, Fernandes R . Were equatorial regions less affected by the 2009 influenza pandemic? The Brazilian experience. PLoS One. 2012; 7(8):e41918. PMC: 3411570. DOI: 10.1371/journal.pone.0041918. View

16.

Thompson W, Comanor L, Shay D . Epidemiology of seasonal influenza: use of surveillance data and statistical models to estimate the burden of disease. J Infect Dis. 2006; 194 Suppl 2:S82-91. DOI: 10.1086/507558. View

17.

Moura F . Influenza in the tropics. Curr Opin Infect Dis. 2010; 23(5):415-20. DOI: 10.1097/QCO.0b013e32833cc955. View

18.

Bellei N, Carraro E, Perosa A, Watanabe A, Arruda E, Granato C . Acute respiratory infection and influenza-like illness viral etiologies in Brazilian adults. J Med Virol. 2008; 80(10):1824-7. PMC: 7166366. DOI: 10.1002/jmv.21295. View

19.

Oliveira W, Carmo E, Penna G, Kuchenbecker R, Santos H, Araujo W . Pandemic H1N1 influenza in Brazil: analysis of the first 34,506 notified cases of influenza-like illness with severe acute respiratory infection (SARI). Euro Surveill. 2009; 14(42). DOI: 10.2807/ese.14.42.19362-en. View

20.

Nunes B, Viboud C, Machado A, Ringholz C, Rebelo-de-Andrade H, Nogueira P . Excess mortality associated with influenza epidemics in Portugal, 1980 to 2004. PLoS One. 2011; 6(6):e20661. PMC: 3119666. DOI: 10.1371/journal.pone.0020661. View