High-throughput Screening Using Dengue Virus Reporter Genomes

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2013 Jul 4

PMID 23821271

Citations 50

Authors

Wolfgang Fischl

Ralf Bartenschlager

Affiliations

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Abstract

Large-scale antiviral drug discovery and systematic identification of host factors promoting or restricting virus replication require robust, scalable, and cost-effective assay systems that allow for high throughput and automation. Here we describe the construction and application of full-length infectious dengue virus reporter genomes for such screening applications.

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