Increased Seizure Latency and Decreased Severity of Pentylenetetrazol-induced Seizures in Mice After Essential Oil Administration

Overview

Journal Epilepsy Res Treat

Date 2013 Jul 3

PMID 23819045

Citations 22

Authors

Eleni Koutroumanidou

Athanasios Kimbaris

Alexandros Kortsaris

Eugenia Bezirtzoglou

Moschos Polissiou

Konstantinos Charalabopoulos

Olga Pagonopoulou

Affiliations

Soon will be listed here.

Abstract

The effect of pretreatment with essential oils (EOs) from eight aromatic plants on the seizure latency and severity of pentylenetetrazol- (PTZ-) induced seizures in mice was evaluated. Weight-dependent doses of Rosmarinus officinalis, Ocimum basilicum, Mentha spicata, Mentha pulegium, Lavandula angustifolia, Mentha piperita, Origanum dictamnus, and Origanum vulgare, isolated from the respective aromatic plants from NE Greece, were administered 60 minutes prior to intraperitoneal (i.p.) injection of a lethal dose of PTZ to eight respective groups of Balb-c mice. Control group received only one i.p. PTZ injection. Motor and behavioral activity of the animals after EOs administration, development of tonic-clonic seizures, seizure latency and severity, and percentage of survival after PTZ administration were determined for each group. All groups of mice treated with the EOs showed reduced activity and stability after the administration of the oil, except for those treated with O. vulgare (100% mortality after the administration of the oil). After PTZ administration, mice from the different groups showed increased latency and reduced severity of seizures (ranging from simple twitches to complete seizures). Mice who had received M. piperita demonstrated no seizures and 100% survival. The different drastic component and its concentration could account for the diversity of anticonvulsant effects.

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