The Influence of Skeletal Muscle on Systemic Aging and Lifespan

Overview

Journal Aging Cell

Specialties Cell Biology
Geriatrics

Date 2013 Jun 28

PMID 23802635

Citations 112

Authors

Fabio Demontis

Rosanna Piccirillo

Alfred L Goldberg

Norbert Perrimon

Affiliations

Soon will be listed here.

Abstract

Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer's and Parkinson's disease. Here, we review recent studies in mammals and Drosophila highlighting how nutrient- and stress-sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle-derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age-related diseases and contribute to the intertissue communication that underlies systemic aging.

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