The Diagnostic Value of Monoclonal Gastric Cancer 7 Antigen: a Systematic Review with Meta-analysis

Overview

Journal Clin Exp Med

Specialty General Medicine

Date 2013 Jun 26

PMID 23797567

Citations 5

Authors

Zongyue Zeng

Sheng Fu

Ping Hu

Liuyang Zhao

Hailong Zhang

Xi Tang

Xiaorong Yang

Zhaofang Zeng

Affiliations

Soon will be listed here.

Abstract

The aim of this study is to explore the clinical characteristic and the diagnostic role of MG7-Ag in detecting gastric cancer (GC) through a systematic review and meta-analysis. Relevant manuscripts aiming at the application of serum MG7-Ag level in GC diagnosis were searched in PubMed, Embase, Chinese National Knowledge Infrastructure, VIP, and Wan Fang Data independently,which were published between January 1, 1980 and February 28, 2013. The pooled sensitivity, specificity,positive diagnostic likelihood ratio (DLR+), negative diagnostic likelihood ratio (DLR-), diagnostic odds ratio,and the area under the summary receiver operating characteristic(AUC) were used to evaluate the value of serum MG7-Ag in diagnosis of GC by using the Meta-DiSc and STATA 11.0 statistical software. 410 manuscripts were retrieved, and 7 manuscripts of high quality including 652 patients were of high quality in this meta-analysis. Overall,the pooled sensitivity, specificity, DLR+, DLR-, and AUC were 0.73 (95 % CI 0.63-0.82), 0.91 (95 % CI 0.84-0.94), 8.59 (95 % CI 5.62-13.11), 0.29 (95 % CI 0.21-0.42), and 0.92 (95 % CI 0.89-0.94), respectively. MG7-Ag is a potential biomarker for the diagnosis of GC.However, more studies are needed to confirm the standard criteria.

Citing Articles

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References

Zamora J, Abraira V, Muriel A, Khan K, Coomarasamy A . Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol. 2006; 6:31. PMC: 1552081. DOI: 10.1186/1471-2288-6-31. View

Miki K . Gastric cancer screening using the serum pepsinogen test method. Gastric Cancer. 2007; 9(4):245-53. DOI: 10.1007/s10120-006-0397-0. View

DerSimonian R, Kacker R . Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials. 2006; 28(2):105-14. DOI: 10.1016/j.cct.2006.04.004. View

Rosman A, Korsten M . Application of summary receiver operating characteristics (sROC) analysis to diagnostic clinical testing. Adv Med Sci. 2008; 52:76-82. View

Jin B, Wang X, Jin Y, Xia W, Chen B, Liu L . Detection of serum gastric cancer-associated MG7-Ag from gastric cancer patients using a sensitive and convenient ELISA method. Cancer Invest. 2009; 27(2):227-33. DOI: 10.1080/07357900802175609. View

Siegel R, Naishadham D, Jemal A . Cancer statistics, 2012. CA Cancer J Clin. 2012; 62(1):10-29. DOI: 10.3322/caac.20138. View

Hanazaki K, Sodeyama H, Yokoyama S, Sode Y, Wakabayashi M, Kawamura N . Postoperative chemotherapy may improve prognosis in unresectable gastric cancer. J Clin Gastroenterol. 1998; 26(4):269-73. DOI: 10.1097/00004836-199806000-00011. View

Egger M, Davey Smith G, Schneider M, Minder C . Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315(7109):629-34. PMC: 2127453. DOI: 10.1136/bmj.315.7109.629. View

Jones C, Athanasiou T . Summary receiver operating characteristic curve analysis techniques in the evaluation of diagnostic tests. Ann Thorac Surg. 2004; 79(1):16-20. DOI: 10.1016/j.athoracsur.2004.09.040. View

10.

Bipat S, Glas A, Slors F, Zwinderman A, Bossuyt P, Stoker J . Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging--a meta-analysis. Radiology. 2004; 232(3):773-83. DOI: 10.1148/radiol.2323031368. View

11.

Ren J, Chen Z, Juan S, Yong X, Pan B, Fan D . Detection of circulating gastric carcinoma-associated antigen MG7-Ag in human sera using an established single determinant immuno-polymerase chain reaction technique. Cancer. 2000; 88(2):280-5. View

12.

Takahashi Y, Takeuchi T, Sakamoto J, Touge T, Mai M, Ohkura H . The usefulness of CEA and/or CA19-9 in monitoring for recurrence in gastric cancer patients: a prospective clinical study. Gastric Cancer. 2003; 6(3):142-5. DOI: 10.1007/s10120-003-0240-9. View

13.

Shi Y, Hu W, Yin F, Sun L, Liu C, Lan M . Regulation of drug sensitivity of gastric cancer cells by human calcyclin-binding protein (CacyBP). Gastric Cancer. 2004; 7(3):160-6. DOI: 10.1007/s10120-004-0286-3. View

14.

Lee J, Son S, Lee C, Ahn S, Park D, Kim H . Morbidity and mortality after laparoscopic gastrectomy for advanced gastric cancer: results of a phase II clinical trial. Surg Endosc. 2013; 27(8):2877-85. DOI: 10.1007/s00464-013-2848-0. View

15.

Liu D, Zhang L, Shen Z, Tan F, Hu Y, Yu J . Increased levels of SLP-2 correlate with poor prognosis in gastric cancer. Gastric Cancer. 2013; 16(4):498-504. DOI: 10.1007/s10120-013-0232-3. View

16.

Tajiri H, Doi T, Endo H, Nishina T, Terao T, Hyodo I . Routine endoscopy using a magnifying endoscope for gastric cancer diagnosis. Endoscopy. 2002; 34(10):772-7. DOI: 10.1055/s-2002-34267. View

17.

Zhang L, Ren J, Pan K, Ma J, Li J, Shen L . Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening. Int J Cancer. 2009; 126(2):469-73. DOI: 10.1002/ijc.24739. View

18.

Nashimoto A, Nakajima T, Furukawa H, Kitamura M, Kinoshita T, Yamamura Y . Randomized trial of adjuvant chemotherapy with mitomycin, Fluorouracil, and Cytosine arabinoside followed by oral Fluorouracil in serosa-negative gastric cancer: Japan Clinical Oncology Group 9206-1. J Clin Oncol. 2003; 21(12):2282-7. DOI: 10.1200/JCO.2003.06.103. View

19.

Wu W, Lee C, Cho C, Fan D, Wu K, Yu J . MicroRNA dysregulation in gastric cancer: a new player enters the game. Oncogene. 2010; 29(43):5761-71. DOI: 10.1038/onc.2010.352. View

20.

Wobbes T, Thomas C, Segers M, Nagengast F . Evaluation of seven tumor markers (CA 50, CA 19-9, CA 19-9 TruQuant, CA 72-4, CA 195, carcinoembryonic antigen, and tissue polypeptide antigen) in the pretreatment sera of patients with gastric carcinoma. Cancer. 1992; 69(8):2036-41. DOI: 10.1002/1097-0142(19920415)69:8<2036::aid-cncr2820690805>3.0.co;2-m. View