Exploiting Paracrine Mechanisms of Tissue Regeneration to Repair Damaged Organs

Overview

Journal Transplant Res

Publisher Biomed Central

Specialty General Surgery

Date 2013 Jun 22

PMID 23786652

Citations 40

Authors

Diana F Anthony

Paul G Shiels

Affiliations

Soon will be listed here.

Abstract

Stem cells have been studied for many years for their potential to repair damaged organs in the human body. Although many different mechanisms have been suggested as to how stem cells may initiate and facilitate repair processes, much remains unknown. Recently, there has been considerable interest in the idea that stem cells may exert their effects in vivo via paracrine actions. This could involve the release of cytokines, growth factors or secreted extracellular vesicles. This article reviews the role that paracrine actions may play in tissue regeneration. In particular, it considers how microvesicles, as a mediator or modulator of paracrine action, can be exploited as a tool for non-cell-based therapies in regenerative medicine.

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