The Complexity, Function and Applications of RNA in Circulation

Overview

Journal Front Genet

Date 2013 Jun 21

PMID 23785385

Citations 23

Authors

Alton Etheridge

Clarissa P C Gomes

Rinaldo W Pereira

David Galas

Kai Wang

Affiliations

Soon will be listed here.

Abstract

Blood carries a wide array of biomolecules, including nutrients, hormones, and molecules that are secreted by cells for specific biological functions. The recent finding of stable RNA of both endogenous and exogenous origin in circulation raises a number of questions and opens a broad, new field: exploring the origins, functions, and applications of these extracellular RNA molecules. These findings raise many important questions, including: what are the mechanisms of export and cellular uptake, what is the nature and source of their stability, what molecules do they interact with in the blood, and what are the possible biological functions of the circulating RNA? This review summarizes some key recent developments in circulating RNA research and discusses some of the open questions in the field.

Citing Articles

RNA-Based Liquid Biopsy in Head and Neck Cancer.

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PMID: 37508579 PMC: 10377854. DOI: 10.3390/cells12141916.

Nucleic acid liquid biopsies in Alzheimer's disease: current state, challenges, and opportunities.

Soelter T, Whitlock J, Williams A, Hardigan A, Lasseigne B Heliyon. 2022; 8(4):e09239.

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Isolation of Cell-Free miRNA from Biological Fluids: Influencing Factors and Methods.

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Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study.

Dias F, Teixeira A, Nogueira I, Morais M, Maia J, Bodo C Int J Mol Sci. 2020; 21(13).

PMID: 32610589 PMC: 7370073. DOI: 10.3390/ijms21134624.

The presence of extracellular microRNAs in the media of cultured Drosophila cells.

Van den Brande S, Gijbels M, Wynant N, Santos D, Mingels L, Gansemans Y Sci Rep. 2018; 8(1):17312.

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