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High-performance Thin Layer Chromatography: A Powerful Analytical Technique in Pharmaceutical Drug Discovery

Overview
Journal Pharm Methods
Specialty Pharmacology
Date 2013 Jun 20
PMID 23781433
Citations 19
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Abstract

Analysis of pharmaceutical and natural compounds and newer drugs is commonly used in all the stages of drug discovery and development process. High-performance thin layer chromatography is one of the sophisticated instrumental techniques based on the full capabilities of thin layer chromatography. The advantages of automation, scanning, full optimization, selective detection principle, minimum sample preparation, hyphenation, and so on enable it to be a powerful analytical tool for chromatographic information of complex mixtures of pharmaceuticals, natural products, clinical samples, food stuffs, and so on.

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References
1.
Gershell L, Atkins J . A brief history of novel drug discovery technologies. Nat Rev Drug Discov. 2003; 2(4):321-7. DOI: 10.1038/nrd1064. View

2.
Rajmane V, Gandhi S, Patil U, Sengar M . High-performance thin-layer chromatographic determination of etoricoxib and thiocolchicoside in combined tablet dosage form. J AOAC Int. 2010; 93(3):783-6. View

3.
Kertesz V, Ford M, Van Berkel G . Automation of a surface sampling probe/electrospray mass spectrometry system. Anal Chem. 2005; 77(22):7183-9. DOI: 10.1021/ac0510742. View

4.
Morlock G, Schwack W . Determination of isopropylthioxanthone (ITX) in milk, yoghurt and fat by HPTLC-FLD, HPTLC-ESI/MS and HPTLC-DART/MS. Anal Bioanal Chem. 2006; 385(3):586-95. DOI: 10.1007/s00216-006-0430-5. View

5.
Sweedler J . The continued evolution of hyphenated instruments. Anal Bioanal Chem. 2002; 373(6):321-2. DOI: 10.1007/s00216-002-1358-z. View