Functions of Cofilin in Cell Locomotion and Invasion

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2013 Jun 20

PMID 23778968

Citations 253

Authors

Jose Javier Bravo-Cordero

Marco A O Magalhaes

Robert J Eddy

Louis Hodgson

John Condeelis

Affiliations

Soon will be listed here.

Abstract

Recently, a consensus has emerged that cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization without changing the rate of G-actin association and dissociation at either filament end. The structural basis of actin filament severing by cofilin is now better understood. These results have been integrated with recently discovered mechanisms for cofilin activation in migrating cells, which led to new models for cofilin function that provide insights into how cofilin regulation determines the temporal and spatial control of cell behaviour.

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