Association of Serum 25-hydroxyvitamin D with Insulin Resistance and β-cell Function in a Healthy Chinese Female Population

Overview

Journal Acta Pharmacol Sin

Specialty Pharmacology

Date 2013 Jun 18

PMID 23770983

Citations 11

Authors

Min-Fang Tao

Zeng Zhang

Yao-hua Ke

Jin-Wei He

Wen-Zhen Fu

Chang-Qing Zhang

Zhen-Lin Zhang

Affiliations

Soon will be listed here.

Abstract

Aim: To assess associations of the serum level of 25-hydroxyvitamin D with insulin resistance and β-cell function in a healthy Chinese female population.

Methods: This cross-sectional study included 1382 female participants free of type 2 diabetes who were recruited in Shanghai. Blood samples were collected within a winter season and the serum levels of 25-hydroxyvitamin D, fasting plasma glucose and insulin, and other biochemical parameters were determined. Insulin resistance and β-cell function were assessed using the homeostasis model assessments of insulin resistance (HOMA-IR) and β-cell function (HOMA-B), respectively.

Results: Multiple linear regression analyses adjusted for age, parathyroid hormone, Ca(2+) and BMI revealed that independent inverse associations existed between the serum level of 25-hydroxyvitamin D and HOMA-IR (P<0.001) and between the serum level of 25-hydroxyvitamin D and HOMA-B (P=0.001).

Conclusion: Serum vitamin D level is significantly and independently associated with insulin resistance and β-cell function in a healthy Chinese female population.

Citing Articles

The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes.

Hashim Z, Qasim Q, ALabbood M Arch Razi Inst. 2023; 77(5):1593-1600.

PMID: 37123134 PMC: 10133625. DOI: 10.22092/ARI.2022.357641.2081.

Association between serum 25-hydroxyvitamin-D and Triglycerides-Glucose index among Indian adolescents.

Mustafa A, Shekhar C BMC Nutr. 2022; 8(1):69.

PMID: 35879737 PMC: 9310494. DOI: 10.1186/s40795-022-00568-x.

Vitamin D Deficiency Is Inversely Associated with Homeostatic Model Assessment of Insulin Resistance.

Rafiq S, Jeppesen P Nutrients. 2021; 13(12).

PMID: 34959910 PMC: 8705502. DOI: 10.3390/nu13124358.

Insulin Resistance Is Inversely Associated with the Status of Vitamin D in Both Diabetic and Non-Diabetic Populations.

Rafiq S, Jeppesen P Nutrients. 2021; 13(6).

PMID: 34063822 PMC: 8224049. DOI: 10.3390/nu13061742.

VITAMIN DEFICIENCY AND INSULIN RESISTANCE IN NONDIABETIC OBESE PATIENTS.

Cigerli O, Parildar H, Dogruk Unal A, Tarcin O, Kut A, Eroglu H Acta Endocrinol (Buchar). 2019; 12(3):319-327.

PMID: 31149107 PMC: 6535262. DOI: 10.4183/aeb.2016.319.

References

Gulseth H, Gjelstad I, Tierney A, Lovegrove J, Defoort C, Blaak E . Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome. Diabetes Care. 2010; 33(4):923-5. PMC: 2845053. DOI: 10.2337/dc09-1692. View

Reis J, von Muhlen D, Kritz-Silverstein D, Wingard D, Barrett-Connor E . Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care. 2007; 30(6):1549-55. DOI: 10.2337/dc06-2438. View

Hou X, Jia W, Bao Y, Lu H, Jiang S, Zuo Y . Risk factors for overweight and obesity, and changes in body mass index of Chinese adults in Shanghai. BMC Public Health. 2008; 8:389. PMC: 2632663. DOI: 10.1186/1471-2458-8-389. View

Timms P, Mannan N, Hitman G, Noonan K, Mills P, Syndercombe-Court D . Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?. QJM. 2002; 95(12):787-96. DOI: 10.1093/qjmed/95.12.787. View

Forouhi N, Luan J, Cooper A, Boucher B, Wareham N . Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes. 2008; 57(10):2619-25. PMC: 2551670. DOI: 10.2337/db08-0593. View

Roislien J, Van Calster B, Hjelmesaeth J . Parathyroid hormone is a plausible mediator for the metabolic syndrome in the morbidly obese: a cross-sectional study. Cardiovasc Diabetol. 2011; 10:17. PMC: 3042378. DOI: 10.1186/1475-2840-10-17. View

Johnson J, Grande J, Roche P, Kumar R . Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas. Am J Physiol. 1994; 267(3 Pt 1):E356-60. DOI: 10.1152/ajpendo.1994.267.3.E356. View

Kabadi S, Lee B, Liu L . Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: results from the NHANES 2001-2006. Diabetes Care. 2012; 35(10):2048-54. PMC: 3447853. DOI: 10.2337/dc12-0235. View

. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004; 363(9403):157-63. DOI: 10.1016/S0140-6736(03)15268-3. View

10.

Liu S, Song Y, Ford E, Manson J, Buring J, Ridker P . Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care. 2005; 28(12):2926-32. DOI: 10.2337/diacare.28.12.2926. View

11.

Chiu K, Chu A, Go V, Saad M . Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004; 79(5):820-5. DOI: 10.1093/ajcn/79.5.820. View

12.

Yamaguchi T, Kanazawa I, Takaoka S, Sugimoto T . Serum calcium is positively correlated with fasting plasma glucose and insulin resistance, independent of parathyroid hormone, in male patients with type 2 diabetes mellitus. Metabolism. 2011; 60(9):1334-9. DOI: 10.1016/j.metabol.2011.02.003. View

13.

Fuleihan G, Deeb M . Hypovitaminosis D in a sunny country. N Engl J Med. 1999; 340(23):1840-1. DOI: 10.1056/NEJM199906103402316. View

14.

Wild S, Roglic G, Green A, Sicree R, King H . Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5):1047-53. DOI: 10.2337/diacare.27.5.1047. View

15.

Pittas A, Dawson-Hughes B, Li T, van Dam R, Willett W, Manson J . Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care. 2006; 29(3):650-6. DOI: 10.2337/diacare.29.03.06.dc05-1961. View

16.

Poomthavorn P, Saowan S, Mahachoklertwattana P, Chailurkit L, Khlairit P . Vitamin D status and glucose homeostasis in obese children and adolescents living in the tropics. Int J Obes (Lond). 2012; 36(4):491-5. DOI: 10.1038/ijo.2011.260. View

17.

Arunabh S, Pollack S, Yeh J, Aloia J . Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab. 2003; 88(1):157-61. DOI: 10.1210/jc.2002-020978. View

18.

Maestro B, Campion J, Davila N, Calle C . Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J. 2000; 47(4):383-91. DOI: 10.1507/endocrj.47.383. View

19.

Buyukinan M, Ozen S, Kokkun S, Saz E . The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents. J Pediatr Endocrinol Metab. 2012; 25(1-2):83-7. DOI: 10.1515/jpem-2011-0426. View

20.

Mattila C, Knekt P, Mannisto S, Rissanen H, Laaksonen M, Montonen J . Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care. 2007; 30(10):2569-70. DOI: 10.2337/dc07-0292. View