Insulin Resistance Is Inversely Associated with the Status of Vitamin D in Both Diabetic and Non-Diabetic Populations

Overview

Journal Nutrients

Date 2021 Jun 2

PMID 34063822

Citations 16

Authors

Shamaila Rafiq

Per Bendix Jeppesen

Affiliations

Soon will be listed here.

Abstract

Vitamin D has been implicated in the regulation of glucose metabolism and insulin resistance. We designed this study to provide evidence that insulin resistance is dependent on the concentration of vitamin D in the body. Forty observational studies of both type 2 diabetes mellitus patients and healthy subjects were included in this meta-analysis. Related articles were searched from Embase, PubMed, and Medline through January 2021. Filters for search were used to obtain more focused results. We used Comprehensive Meta-Analysis Version 3 for the construction of forest plots. RevMan software version 5.3 was used to build the risk of bias tables and summary plots. The observational studies included in this systematic review and meta-analysis showed an inverse relationship of insulin resistance with the status of vitamin D both in non-diabetic ( = -0.188; 95% CI = -0.141 to -0.234; = 0.000) and diabetic ( = -0.255; 95% CI = -0.392 to -0.107, = 0.001) populations. From the meta-analysis we concluded that hypovitaminosis D is related to increased levels of insulin resistance in both type 2 diabetes patients and the healthy population all over the world.

Citing Articles

An evidence-based assessment of the nutritional recommendations for the prevention of diabetes mellitus.

Kechagia I, Panagiotakos D Hormones (Athens). 2024; .

PMID: 39287760 DOI: 10.1007/s42000-024-00604-4.

Vitamin D and risk of developing type 2 diabetes in the SUN project: a prospective cohort study.

Valer-Martinez A, Sayon-Orea C, Martinez J, Basterra-Gortari F, Martinez-Gonzalez M, Bes-Rastrollo M J Endocrinol Invest. 2024; 47(9):2313-2323.

PMID: 38459212 PMC: 11368983. DOI: 10.1007/s40618-024-02324-3.

Cross-sectional study of the associations between circulating vitamin D concentrations and insulin resistance in children aged 9-10 years of South Asian, black African Caribbean and white European origins.

Donin A, Nightingale C, Sattar N, Fraser W, Owen C, Cook D J Epidemiol Community Health. 2023; .

PMID: 38123968 PMC: 11045364. DOI: 10.1136/jech-2023-220626.

1α,25(OH)D ameliorates insulin resistance by alleviating γδ T cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression.

Li P, Li K, Yuan W, Xu Y, Li P, Wu R Theranostics. 2023; 13(15):5290-5304.

PMID: 37908738 PMC: 10614678. DOI: 10.7150/thno.84645.

Incidence of Vitamin D Deficiency and Its Association With Microalbuminuria in Patients With Type 2 Diabetes Mellitus.

Riaz M, Jamil A, Yousaf H, Hassan M, Sohaib M, Babar S Cureus. 2023; 15(9):e45854.

PMID: 37881399 PMC: 10596171. DOI: 10.7759/cureus.45854.

References

Yin X, Sun Q, Zhang X, Lu Y, Sun C, Cui Y . Serum 25(OH)D is inversely associated with metabolic syndrome risk profile among urban middle-aged Chinese population. Nutr J. 2012; 11:68. PMC: 3508942. DOI: 10.1186/1475-2891-11-68. View

Kabadi S, Lee B, Liu L . Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: results from the NHANES 2001-2006. Diabetes Care. 2012; 35(10):2048-54. PMC: 3447853. DOI: 10.2337/dc12-0235. View

Kim J . Association between serum vitamin D, parathyroid hormone and metabolic syndrome in middle-aged and older Korean adults. Eur J Clin Nutr. 2014; 69(4):425-30. DOI: 10.1038/ejcn.2014.192. View

Li L, Yin X, Yao C, Zhu X, Wu X . Serum 25-hydroxyvitamin D, parathyroid hormone, and their association with metabolic syndrome in Chinese. Endocrine. 2013; 44(2):465-72. DOI: 10.1007/s12020-013-9885-2. View

Sheth J, Shah A, Sheth F, Trivedi S, Lele M, Shah N . Does vitamin D play a significant role in type 2 diabetes?. BMC Endocr Disord. 2015; 15:5. PMC: 4357062. DOI: 10.1186/s12902-015-0003-8. View

Alam U, Arul-Devah V, Javed S, Malik R . Vitamin D and Diabetic Complications: True or False Prophet?. Diabetes Ther. 2016; 7(1):11-26. PMC: 4801816. DOI: 10.1007/s13300-016-0159-x. View

Gannage-Yared M, Chedid R, Khalife S, Azzi E, Zoghbi F, Halaby G . Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young Middle-Eastern population. Eur J Endocrinol. 2009; 160(6):965-71. DOI: 10.1530/EJE-08-0952. View

Chiu K, Chu A, Go V, Saad M . Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004; 79(5):820-5. DOI: 10.1093/ajcn/79.5.820. View

Esteghamati A, Aryan Z, Esteghamati A, Nakhjavani M . Vitamin D deficiency is associated with insulin resistance in nondiabetics and reduced insulin production in type 2 diabetics. Horm Metab Res. 2014; 47(4):273-9. DOI: 10.1055/s-0034-1389903. View

10.

Tosunbayraktar G, Bas M, Kut A, Buyukkaragoz A . Low serum 25(OH)D levels are assocıated to hıgher BMI and metabolic syndrome parameters in adult subjects in Turkey. Afr Health Sci. 2016; 15(4):1161-9. PMC: 4765420. DOI: 10.4314/ahs.v15i4.15. View

11.

Schwartz S, Epstein S, Corkey B, Grant S, Gavin Iii J, Aguilar R . A Unified Pathophysiological Construct of Diabetes and its Complications. Trends Endocrinol Metab. 2017; 28(9):645-655. DOI: 10.1016/j.tem.2017.05.005. View

12.

Bril F, Maximos M, Portillo-Sanchez P, Biernacki D, Lomonaco R, Subbarayan S . Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis. J Hepatol. 2014; 62(2):405-11. DOI: 10.1016/j.jhep.2014.08.040. View

13.

Gulseth H, Gjelstad I, Tierney A, Lovegrove J, Defoort C, Blaak E . Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome. Diabetes Care. 2010; 33(4):923-5. PMC: 2845053. DOI: 10.2337/dc09-1692. View

14.

Zoppini G, Galletti A, Targher G, Brangani C, Pichiri I, Negri C . Glycated haemoglobin is inversely related to serum vitamin D levels in type 2 diabetic patients. PLoS One. 2013; 8(12):e82733. PMC: 3865107. DOI: 10.1371/journal.pone.0082733. View

15.

Al-Daghri N, Al-Attas O, Al-Okail M, Alkharfy K, Al-Yousef M, Nadhrah H . Severe hypovitaminosis D is widespread and more common in non-diabetics than diabetics in Saudi adults. Saudi Med J. 2010; 31(7):775-80. View

16.

Lim S, Kim M, Choi S, Shin C, Park K, Jang H . Association of vitamin D deficiency with incidence of type 2 diabetes in high-risk Asian subjects. Am J Clin Nutr. 2013; 97(3):524-30. PMC: 3578401. DOI: 10.3945/ajcn.112.048496. View

17.

Alkharfy K, Al-Daghri N, Sabico S, Al-Othman A, Moharram O, Alokail M . Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens: a one-year prospective study. Cardiovasc Diabetol. 2013; 12:113. PMC: 3750473. DOI: 10.1186/1475-2840-12-113. View

18.

Generini S, Tuveri M, Cerinic M, Mastinu F, Manni L, Aloe L . Topical application of nerve growth factor in human diabetic foot ulcers. A study of three cases. Exp Clin Endocrinol Diabetes. 2004; 112(9):542-4. DOI: 10.1055/s-2004-821313. View

19.

Khor G, Chee W, Shariff Z, Poh B, Arumugam M, Rahman J . High prevalence of vitamin D insufficiency and its association with BMI-for-age among primary school children in Kuala Lumpur, Malaysia. BMC Public Health. 2011; 11:95. PMC: 3045951. DOI: 10.1186/1471-2458-11-95. View

20.

Palomer X, Gonzalez-Clemente J, Blanco-Vaca F, Mauricio D . Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab. 2008; 10(3):185-97. DOI: 10.1111/j.1463-1326.2007.00710.x. View