The Transcription Factor GATA4 is Required for Follicular Development and Normal Ovarian Function

Overview

Journal Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2013 Jun 18

PMID 23769843

Citations 30

Authors

Evgeni Efimenko

Maria B Padua

Nikolay L Manuylov

Shawna C Fox

Deborah A Morse

Sergei G Tevosian

Affiliations

Soon will be listed here.

Abstract

Sex determination in mammals requires interaction between the transcription factor GATA4 and its cofactor FOG2. We have recently described the function of both proteins in testis development beyond the sex determination stage; their roles in the postnatal ovary, however, remain to be defined. Here, we use gene targeting in mice to determine the requirement of GATA4 and FOG2 in ovarian development and folliculogenesis. The results from this study identify an essential role of the GATA4 protein in the ovarian morphogenetic program. We show that in contrast to the sex determination phase, which relies on the GATA4-FOG2 complex, the subsequent regulation of ovarian differentiation is dependent upon GATA4 but not FOG2. The loss of Gata4 expression within the ovary results in impaired granulosa cell proliferation and theca cell recruitment as well as fewer primordial follicles in the ovarian cortex, causing a failure in follicular development. Preantral follicular atresia is observed within the few follicles that develop despite Gata4 deficiency. The depletion of the follicular pool in GATA4 deficient ovary results in the formation of ovarian cysts and sterility.

Citing Articles

FOXL2 interaction with different binding partners regulates the dynamics of ovarian development.

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Single-cell RNA-seq identified novel genes involved in primordial follicle formation.

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Bone morphogenetic protein 2- and estradiol-17β-induced changes in ovarian transcriptome during primordial follicle formation†.

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