In Vivo Evidence for a Prodrug Activation Mechanism During Colibactin Maturation

Overview

Journal Chembiochem

Specialty Biochemistry

Date 2013 Jun 8

PMID 23744512

Citations 57

Authors

Xiaoying Bian

Jun Fu

Alberto Plaza

Jennifer Herrmann

Dominik Pistorius

A Francis Stewart

Youming Zhang

Rolf Muller

Affiliations

Soon will be listed here.

Abstract

Releasing the cytopath: We have identified an N-myristoyl-D-asparagine (1) as the free N-terminal prodrug scaffold in cytopathogenic Escherichia coli strains expressing the colibactin gene cluster. Colibactin is released in vivo upon cleavage of precolibactin. We provide for the first time in vivo evidence of the prodrug-like release mechanism of colibactin.

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