The Effects of Cholecystokinin Octapeptide on Human Isolated Alimentary Muscle

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1990 May 1

PMID 2372654

Citations 3

Authors

M Damato

I F Stamford

A Bennett

Affiliations

Soon will be listed here.

Abstract

1. We studied cholecystokinin octapeptide (CCK-OP) for its motor effects and sites of action on human isolated muscle from stomach, small intestine and colon. 2. CCK-OP induced a concentration-dependent contraction of all the longitudinal muscles and of circular muscle from the stomach and large intestine. The peptide acted directly on these muscles at a site not involving muscarinic receptors. 3. CCK-OP relaxed the circular muscle of the small intestine and/or reduced the contractions to acetylcholine, by stimulating intramural postganglionic inhibitory neurones.

Citing Articles

Role of CCK/gastrin receptors in gastrointestinal/metabolic diseases and results of human studies using gastrin/CCK receptor agonists/antagonists in these diseases.

Berna M, Jensen R Curr Top Med Chem. 2007; 7(12):1211-31.

PMID: 17584143 PMC: 2718729. DOI: 10.2174/156802607780960519.

Involvement of endogenous CCK and CCK1 receptors in colonic motor function.

Varga G, Balint A, Burghardt B, DAmato M Br J Pharmacol. 2004; 141(8):1275-84.

PMID: 15100163 PMC: 1574909. DOI: 10.1038/sj.bjp.0705769.

Studies of three non-peptide cholecystokinin antagonists (devazepide, lorglumide and loxiglumide) in human isolated alimentary muscle and guinea-pig ileum.

Damato M, Stamford I, Bennett A Br J Pharmacol. 1991; 102(2):391-5.

PMID: 2015421 PMC: 1918051. DOI: 10.1111/j.1476-5381.1991.tb12184.x.

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