Immune and Inflammatory Role in Renal Disease

Overview

Journal Compr Physiol

Specialty Physiology

Date 2013 May 31

PMID 23720336

Citations 158

Authors

John D Imig

Michael J Ryan

Affiliations

Soon will be listed here.

Abstract

Chronic and acute renal diseases, irrespective of the initiating cause, have inflammation and immune system activation as a common underlying mechanism. The purpose of this review is to provide a broad overview of immune cells and inflammatory proteins that contribute to the pathogenesis of renal disease, and to discuss some of the physiological changes that occur in the kidney as a result of immune system activation. An overview of common forms of acute and chronic renal disease is provided, followed by a discussion of common therapies that have anti-inflammatory or immunosuppressive effects in the treatment of renal disease.

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