Weakly Stable Regions and Protein-protein Interactions in Beta-barrel Membrane Proteins

Overview

Journal Curr Pharm Des

Publisher Bentham Science Publishers

Date 2013 May 30

PMID 23713778

Citations 5

Authors

Hammad Naveed

Jie Liang

Affiliations

Soon will be listed here.

Abstract

We briefly discuss recent progress in computational characterization of the sequence and structural properties of β-barrel membrane properties. We discuss the emerging concept of weakly stable regions in β-barrel membrane proteins, computational methods to identify these regions and mechanisms adopted by β-barrel membrane proteins in nature to stabilize them. We further discuss computational methods to identify protein-protein interactions in β-barrel membrane proteins and recent experimental studies that aim at altering the biophysical properties including oligomerization state and stability of β-barrel membrane proteins based on the emerging organization principles of these proteins from recent computational studies.

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