Chromatin Insulators: Linking Genome Organization to Cellular Function

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2013 May 28

PMID 23706817

Citations 124

Authors

Jennifer E Phillips-Cremins

Victor G Corces

Affiliations

Soon will be listed here.

Abstract

A growing body of evidence suggests that insulators have a primary role in orchestrating the topological arrangement of higher-order chromatin architecture. Insulator-mediated long-range interactions can influence the epigenetic status of the genome and, in certain contexts, may have important effects on gene expression. Here we discuss higher-order chromatin organization as a unifying mechanism for diverse insulator actions across the genome.

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