Comment on "ApoE-directed Therapeutics Rapidly Clear β-amyloid and Reverse Deficits in AD Mouse Models"

Overview

Journal Science

Specialty Science

Date 2013 May 25

PMID 23704554

Citations 86

Authors

Ina Tesseur

Adrian C Lo

Anouk Roberfroid

Sofie Dietvorst

Bianca Van Broeck

Marianne Borgers

Harrie Gijsen

Diederik Moechars

Marc Mercken

John Kemp

Rudi DHooge

Bart De Strooper

Affiliations

Soon will be listed here.

Abstract

Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) tested bexarotene as a potential β-amyloid-lowering drug for Alzheimer's disease (AD). We were not able to reproduce the described effects in several animal models. Drug formulation appears very critical. Our data call for extreme caution when considering this compound for use in AD patients.

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