Plug-and-play Modules for Flexible Radiosynthesis

Overview

Journal Appl Radiat Isot

Specialties Environmental Health
Nuclear Medicine

Date 2013 May 25

PMID 23702795

Citations 4

Authors

Henry Herman

Graciela Flores

Kevin Quinn

Mark Eddings

Sebastian Olma

Melissa D Moore

Huijiang Ding

Krzysztof P Bobinski

Mingwei Wang

Dirk Williams

Darin Wiliams

Clifton Kwang-Fu Shen

Michael E Phelps

R Michael van Dam

Affiliations

Soon will be listed here.

Abstract

We present a plug-and-play radiosynthesis platform and accompanying computer software based on modular subunits that can easily and flexibly be configured to implement a diverse range of radiosynthesis protocols. Modules were developed that perform: (i) reagent storage and delivery, (ii) evaporations and sealed reactions, and (iii) cartridge-based purifications. The reaction module incorporates a simple robotic mechanism that removes tubing from the vessel and replaces it with a stopper prior to sealed reactions, enabling the system to withstand high pressures and thus provide tremendous flexibility in choice of solvents and temperatures. Any number of modules can rapidly be connected together using only a few fluidic connections to implement a particular synthesis, and the resulting system is controlled in a semi-automated fashion by a single software interface. Radiosyntheses of 2-[(18)F]fluoro-2-deoxy-d-glucose ([(18)F]FDG), 1-[(18)F]fluoro-4-nitrobenzene ([(18)F]FNB), and 2'-deoxy-2'-[(18)F]fluoro-1-β-d-arabinofuranosyl cytosine (d-[(18)F]FAC) were performed to validate the system and demonstrate its versatility.

Citing Articles

Production of diverse PET probes with limited resources: 24 F-labeled compounds prepared with a single radiosynthesizer.

Collins J, Waldmann C, Drake C, Slavik R, Ha N, Sergeev M Proc Natl Acad Sci U S A. 2017; 114(43):11309-11314.

PMID: 29073049 PMC: 5664529. DOI: 10.1073/pnas.1710466114.

Compact microfluidic device for rapid concentration of PET tracers.

Tseng W, van Dam R Lab Chip. 2014; 14(13):2293-302.

PMID: 24825578 PMC: 4465334. DOI: 10.1039/c4lc00286e.

Simplified programming and control of automated radiosynthesizers through unit operations.

Claggett S, Quinn K, Lazari M, Moore M, van Dam R EJNMMI Res. 2013; 3(1):53.

PMID: 23855995 PMC: 3717018. DOI: 10.1186/2191-219X-3-53.

ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers.

Lazari M, Quinn K, Claggett S, Collins J, Shah G, Herman H EJNMMI Res. 2013; 3(1):52.

PMID: 23849185 PMC: 3717127. DOI: 10.1186/2191-219X-3-52.

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