Vitamin D and Aging

Overview

Journal Endocrinol Metab Clin North Am

Publisher Elsevier

Specialty Endocrinology

Date 2013 May 25

PMID 23702404

Citations 126

Authors

J Christopher Gallagher

Affiliations

Soon will be listed here.

Abstract

Age-related changes affect vitamin D metabolism and increase the requirement for vitamin D in the elderly. Also there is an age related decrease in calcium absorption and a higher calcium intake is needed. Increasing calcium from dietary sources may be better than supplements, and requires increasing the intake of dairy products or other and calcium-fortified foods. Evidence suggests that vitamin D and calcium nutrition can be improved in the elderly by increasing the vitamin D intake to 800 IU daily together with a total calcium intake of 1000 mg daily. This combination is a simple, inexpensive strategy that can reduce fractures in institutionalized individuals by 30%.

Citing Articles

Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review.

Schmieder H, Leischner C, Piotrowsky A, Marongiu L, Venturelli S, Burkard M Immun Ageing. 2025; 22(1):8.

PMID: 39962579 PMC: 11831837. DOI: 10.1186/s12979-025-00501-3.

Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing-Remitting Multiple Sclerosis.

Lis M, Niedziela N, Adamczyk-Zostawa J, Zalejska-Fiolka J, Szczygiel J, Sowa A Curr Issues Mol Biol. 2024; 46(12):14119-14131.

PMID: 39727973 PMC: 11674365. DOI: 10.3390/cimb46120845.

The Effect of Vitamin D Supplementation on Quality of Life in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy: A Single-Blind, Randomized Controlled Trial.

Perinandika T, Rudiman R, Purnama A J Gastrointest Cancer. 2024; 56(1):22.

PMID: 39557774 DOI: 10.1007/s12029-024-01142-3.

Impact of Vitamin D Deficiency on Ischemic Stroke Severity: Insights from a Prospective Study.

Simon J, Sriharsha T, Perumal Kumaresan A, Chand U, Bose S Cureus. 2024; 16(9):e69376.

PMID: 39403669 PMC: 11472005. DOI: 10.7759/cureus.69376.

The correlation between serum vitamin D status and the occurrence of diabetic foot ulcers: a comprehensive systematic review and meta-analysis.

Tang W, Chen D, Chen L, Liu G, Sun S, Wang C Sci Rep. 2024; 14(1):21932.

PMID: 39304728 PMC: 11415517. DOI: 10.1038/s41598-024-73133-0.

References

Francis R, Peacock M, Barkworth S . Renal impairment and its effects on calcium metabolism in elderly women. Age Ageing. 1984; 13(1):14-20. DOI: 10.1093/ageing/13.1.14. View

Melamed M, Michos E, Post W, Astor B . 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008; 168(15):1629-37. PMC: 2677029. DOI: 10.1001/archinte.168.15.1629. View

Taylor C, Carriquiry A, Bailey R, Sempos C, Yetley E . Appropriateness of the probability approach with a nutrient status biomarker to assess population inadequacy: a study using vitamin D. Am J Clin Nutr. 2012; 97(1):72-8. PMC: 3522142. DOI: 10.3945/ajcn.112.046094. View

Bruyere O, Decock C, Delhez M, Collette J, Reginster J . Highest prevalence of vitamin D inadequacy in institutionalized women compared with noninstitutionalized women: a case-control study. Womens Health (Lond). 2008; 5(1):49-54. DOI: 10.2217/17455057.5.1.49. View

Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Thomsen J . Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med. 2000; 247(2):260-8. DOI: 10.1046/j.1365-2796.2000.00595.x. View

Bullamore J, Wilkinson R, Gallagher J, Nordin B, Marshall D . Effect of age on calcium absorption. Lancet. 1970; 2(7672):535-7. DOI: 10.1016/s0140-6736(70)91344-9. View

Kutuzova G, Sundersingh F, Vaughan J, Tadi B, Ansay S, Christakos S . TRPV6 is not required for 1alpha,25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo. Proc Natl Acad Sci U S A. 2008; 105(50):19655-9. PMC: 2605002. DOI: 10.1073/pnas.0810761105. View

Gallagher J, Sai A . Vitamin D insufficiency, deficiency, and bone health. J Clin Endocrinol Metab. 2010; 95(6):2630-3. PMC: 2902062. DOI: 10.1210/jc.2010-0918. View

Benn B, Ajibade D, Porta A, Dhawan P, Hediger M, Peng J . Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology. 2008; 149(6):3196-205. PMC: 2408805. DOI: 10.1210/en.2007-1655. View

10.

Cauley J, Parimi N, Ensrud K, Bauer D, Cawthon P, Cummings S . Serum 25-hydroxyvitamin D and the risk of hip and nonspine fractures in older men. J Bone Miner Res. 2009; 25(3):545-53. PMC: 3121172. DOI: 10.1359/jbmr.090826. View

11.

Kinyamu H, Gallagher J, Petranick K, Ryschon K . Effect of parathyroid hormone (hPTH[1-34]) infusion on serum 1,25-dihydroxyvitamin D and parathyroid hormone in normal women. J Bone Miner Res. 1996; 11(10):1400-5. DOI: 10.1002/jbmr.5650111005. View

12.

Deluca H . Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004; 80(6 Suppl):1689S-96S. DOI: 10.1093/ajcn/80.6.1689S. View

13.

Gaugris S, Heaney R, Boonen S, Kurth H, Bentkover J, Sen S . Vitamin D inadequacy among post-menopausal women: a systematic review. QJM. 2005; 98(9):667-76. DOI: 10.1093/qjmed/hci096. View

14.

Holick M, Binkley N, Bischoff-Ferrari H, Gordon C, Hanley D, Heaney R . Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011; 96(7):1911-30. DOI: 10.1210/jc.2011-0385. View

15.

Cauley J, Danielson M, Boudreau R, Barbour K, Horwitz M, Bauer D . Serum 25-hydroxyvitamin D and clinical fracture risk in a multiethnic cohort of women: the Women's Health Initiative (WHI). J Bone Miner Res. 2011; 26(10):2378-88. PMC: 3304434. DOI: 10.1002/jbmr.449. View

16.

Priemel M, von Domarus C, Klatte T, Kessler S, Schlie J, Meier S . Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res. 2009; 25(2):305-12. DOI: 10.1359/jbmr.090728. View

17.

Need A, OLoughlin P, Morris H, Coates P, Horowitz M, Nordin B . Vitamin D metabolites and calcium absorption in severe vitamin D deficiency. J Bone Miner Res. 2008; 23(11):1859-63. DOI: 10.1359/jbmr.080607. View

18.

Chung M, Lee J, Terasawa T, Lau J, Trikalinos T . Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2011; 155(12):827-38. DOI: 10.7326/0003-4819-155-12-201112200-00005. View

19.

Ensrud K, Taylor B, Paudel M, Cauley J, Cawthon P, Cummings S . Serum 25-hydroxyvitamin D levels and rate of hip bone loss in older men. J Clin Endocrinol Metab. 2009; 94(8):2773-80. PMC: 2730873. DOI: 10.1210/jc.2008-2786. View

20.

Dukas L, Schacht E, Runge M . Independent from muscle power and balance performance, a creatinine clearance below 65 ml/min is a significant and independent risk factor for falls and fall-related fractures in elderly men and women diagnosed with osteoporosis. Osteoporos Int. 2009; 21(7):1237-45. DOI: 10.1007/s00198-009-1064-1. View