The Effect of Vitamin D Supplementation to Parameter of Sarcopenia in Elderly People: a Systematic Review and Meta-Analysis

Overview

Journal Can Geriatr J

Specialty Geriatrics

Date 2024 Mar 4

PMID 38433884

Authors

Novira Widajanti

Usman Hadi

Soebagijo Adi Soelistijo

Noer Halimatus Syakdiyah

Roudhona Rosaudyn

Hendy Bhaskara Perdana Putra

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D plays an essential role in promoting skeletal muscle metabolism. Several studies show that vitamin D may help the elderly prevent sarcopenia. Nevertheless, the outcome remains debatable. Our meta-analysis aimed to summarize the effect of vitamin D supplementation on sarcopenia-related parameters.

Methods: We searched PubMed, Cochrane, Springer, SAGE Journals, and Scopus abstracts on 10th December 2021 for relevant studies. We included articles that studied the effect of vitamin D on muscle mass, muscle strength, and physical performance. The aim was to measure the muscle mass, muscle strength, and physical performance both at baseline and at the end of the intervention.

Results: A total of 6,628 participants from 35 studies were included. Most of the studies used oral vitamin D, whereas only one study used intramuscular injection. The effect of vitamin D supplementation showed no effect on appendicular skeletal muscle mass (SMD = .05 [95% CI, .33 - .44], = .79). Regarding muscle strength, vitamin D supplementation did not have a significant effect on muscle strength which is handgrip strength ( = .26). Respecting physical performance, vitamin D supplementation did not affect TUG (Timed Up and Go) ( = .45).

Conclusions: Vitamin D supplementation had minimal effect on sarcopenia-related parameters. Further research into understanding the role of Vitamin D in preventing the progressivity of sarcopenia still needs to be explored.

Citing Articles

In elderly individuals, the effectiveness of sensorimotor training on postural control and muscular strength is comparable to resistance-endurance training.

Varjan M, Ziska Bohmerova L, Oreska L, Schickhofer P, Hamar D Front Physiol. 2024; 15:1386537.

PMID: 39234306 PMC: 11371677. DOI: 10.3389/fphys.2024.1386537.

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