The Vitamin D Receptor (VDR) Gene Polymorphisms in Turkish Brain Cancer Patients

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2013 May 22

PMID 23691496

Citations 9

Authors

Bahar Toptas

Ali Metin Kafadar

Canan Cacina

Saime Turan

Leman Melis Yurdum

Nihal Yigitbasi

Muhammed Oguz Gokce

Umit Zeybek

Ilhan Yaylim

Affiliations

Soon will be listed here.

Abstract

Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma. Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP). Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles. Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.

Citing Articles

Anti-tumor effects of vitamin D in glioblastoma: mechanism and therapeutic implications.

Lo C, Kiang K, Leung G Lab Invest. 2021; 102(2):118-125.

PMID: 34504307 DOI: 10.1038/s41374-021-00673-8.

Association of Vitamin D with the TaqI Polymorphism of the VDR Gene in Older Women Attending the Basic Health Unit of the Federal District, DF (Brazil).

Freitas R, Fratelli C, de Souza Silva C, Lima L, Stival M, Rodrigues da Silva I J Aging Res. 2020; 2020:7145193.

PMID: 33029399 PMC: 7532410. DOI: 10.1155/2020/7145193.

Molecular Mechanism of Cancer Susceptibility Associated with Fok1 Single Nucleotide Polymorphism of VDR in Relation to Breast Cancer.

Raza S, Dhasmana A, Bhatt M, Lohani M, Arif J Asian Pac J Cancer Prev. 2019; 20(1):199-206.

PMID: 30678432 PMC: 6485585. DOI: 10.31557/APJCP.2019.20.1.199.

Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma.

Singhal S, Kapoor H, Subramanian S, Agrawal D, Mittal S J Gastrointest Cancer. 2018; 50(4):867-878.

PMID: 30187205 DOI: 10.1007/s12029-018-0164-6.

Investigation of Vitamin D Receptor Gene Polymorphism in Pediatric Patients with Brain Cancer.

Yilmaz B, Tokuc G, Koc A, Yesil E Indian J Med Paediatr Oncol. 2017; 38(2):128-132.

PMID: 28900319 PMC: 5582548. DOI: 10.4103/ijmpo.ijmpo_22_16.

References

Amano Y, Komiyama K, Makishima M . Vitamin D and periodontal disease. J Oral Sci. 2009; 51(1):11-20. DOI: 10.2334/josnusd.51.11. View

Raimondi S, Johansson H, Maisonneuve P, Gandini S . Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk. Carcinogenesis. 2009; 30(7):1170-80. DOI: 10.1093/carcin/bgp103. View

Qi X, Pramanik R, Wang J, Schultz R, Maitra R, Han J . The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. J Biol Chem. 2002; 277(29):25884-92. DOI: 10.1074/jbc.M203039200. View

Miller S, Dykes D, Polesky H . A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988; 16(3):1215. PMC: 334765. DOI: 10.1093/nar/16.3.1215. View

Trouillas P, Honnorat J, Bret P, Jouvet A, Gerard J . Redifferentiation therapy in brain tumors: long-lasting complete regression of glioblastomas and an anaplastic astrocytoma under long term 1-alpha-hydroxycholecalciferol. J Neurooncol. 2001; 51(1):57-66. DOI: 10.1023/a:1006437003352. View

McGrath J, Feron F, Burne T, Mackay-Sim A, Eyles D . Vitamin D3-implications for brain development. J Steroid Biochem Mol Biol. 2004; 89-90(1-5):557-60. DOI: 10.1016/j.jsbmb.2004.03.070. View

Tseng M, Breslow R, Graubard B, Ziegler R . Dairy, calcium, and vitamin D intakes and prostate cancer risk in the National Health and Nutrition Examination Epidemiologic Follow-up Study cohort. Am J Clin Nutr. 2005; 81(5):1147-54. DOI: 10.1093/ajcn/81.5.1147. View

Slattery M . Vitamin D receptor gene (VDR) associations with cancer. Nutr Rev. 2007; 65(8 Pt 2):S102-4. PMC: 2409269. DOI: 10.1111/j.1753-4887.2007.tb00332.x. View

Sutton A, Zhang X, Ellison T, MacDonald P . The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation. Mol Endocrinol. 2005; 19(9):2234-44. DOI: 10.1210/me.2005-0081. View

10.

Slattery M, Sweeney C, Murtaugh M, Ma K, Caan B, Potter J . Associations between vitamin D, vitamin D receptor gene and the androgen receptor gene with colon and rectal cancer. Int J Cancer. 2006; 118(12):3140-6. DOI: 10.1002/ijc.21791. View

11.

Fisher J, Schwartzbaum J, Wrensch M, Wiemels J . Epidemiology of brain tumors. Neurol Clin. 2007; 25(4):867-90, vii. DOI: 10.1016/j.ncl.2007.07.002. View

12.

Mogi A, Hirato J, Kosaka T, Yamaki E, Kuwano H . Primary mediastinal atypical meningioma: report of a case and literature review. World J Surg Oncol. 2012; 10:17. PMC: 3278378. DOI: 10.1186/1477-7819-10-17. View

13.

Mathers J, Strathdee G, Relton C . Induction of epigenetic alterations by dietary and other environmental factors. Adv Genet. 2010; 71:3-39. DOI: 10.1016/B978-0-12-380864-6.00001-8. View

14.

Rajaraman P, Melin B, Wang Z, McKean-Cowdin R, Michaud D, Wang S . Genome-wide association study of glioma and meta-analysis. Hum Genet. 2012; 131(12):1877-88. PMC: 3761216. DOI: 10.1007/s00439-012-1212-0. View

15.

Abe E, Miyaura C, Sakagami H, Takeda M, Konno K, Yamazaki T . Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A. 1981; 78(8):4990-4. PMC: 320317. DOI: 10.1073/pnas.78.8.4990. View

16.

Bhanushali A, Lajpal N, Kulkarni S, Chavan S, Bagadi S, Das B . Frequency of fokI and taqI polymorphism of vitamin D receptor gene in Indian population and its association with 25-hydroxyvitamin D levels. Indian J Hum Genet. 2010; 15(3):108-13. PMC: 2922626. DOI: 10.4103/0971-6866.60186. View

17.

Kure S, Nosho K, Baba Y, Irahara N, Shima K, Ng K . Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2009; 18(10):2765-72. PMC: 2768137. DOI: 10.1158/1055-9965.EPI-09-0490. View

18.

Ting H, Yasmin-Karim S, Yan S, Hsu J, Lin T, Zeng W . A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D. Cancer Res. 2011; 72(4):958-68. PMC: 6616526. DOI: 10.1158/0008-5472.CAN-11-0042. View

19.

Sweeney C, Curtin K, Murtaugh M, Caan B, Potter J, Slattery M . Haplotype analysis of common vitamin D receptor variants and colon and rectal cancers. Cancer Epidemiol Biomarkers Prev. 2006; 15(4):744-9. DOI: 10.1158/1055-9965.EPI-05-0814. View

20.

Amor K, Rashid R, Mirmirani P . Does D matter? The role of vitamin D in hair disorders and hair follicle cycling. Dermatol Online J. 2010; 16(2):3. View