» Articles » PMID: 19403841

Review and Meta-analysis on Vitamin D Receptor Polymorphisms and Cancer Risk

Overview
Journal Carcinogenesis
Specialty Oncology
Date 2009 May 1
PMID 19403841
Citations 103
Authors
Affiliations
Soon will be listed here.
Abstract

It was suggested that vitamin D levels influence cancer development. The vitamin D receptor (VDR) is a crucial mediator for the cellular effects of vitamin D. Results from previous studies on the association of VDR polymorphisms with different cancer types are somewhat contradictory, and the role of VDR in the etiology of cancer is still equivocal. We therefore performed a meta-analysis on the association between the two most studied VDR polymorphisms (FokI and BsmI) and any cancer site. Up to January 2009, we identified 67 independent studies. We used random-effects models to provide summary odds ratio (SOR) for VDR polymorphisms and cancer. We tested homogeneity of effects across studies and publication bias and explored between-study heterogeneity. When comparing FokI ff with FF carriers, we found a significant increase in skin cancer [SOR; 95% confidence intervals (CIs): 1.30; 1.04-1.61] and breast cancer (SOR; 95%CI: 1.14; 1.03-1.27) risk. For the same genotype comparison, we found a significantly higher risk of cancer when we pooled estimates from cancer sites possibly associated with vitamin D levels (prostate, breast, skin, ovary, non-Hodgkin lymphoma and colorectal). A significant reduction in prostate cancer risk was observed for carriers of BsmI Bb compared with bb genotype (SOR; 95%CI: 0.83; 0.69-0.99). In Caucasian populations, both Bb and BB carriers had a significant reduced risk of cancer at any site. In conclusion, this meta-analysis showed that VDR FokI and BsmI polymorphisms might modulate the risk of cancer of breast, skin and prostate and possibly affect cancer risk at any site in Caucasians.

Citing Articles

Are Pediatric Cancer Patients a Risk Group for Vitamin D Deficiency? A Systematic Review.

Alexandru A, Ivan C, Tanasescu S, Oprisoni L, Dragomir T, Varga N Cancers (Basel). 2025; 16(24.

PMID: 39766100 PMC: 11674856. DOI: 10.3390/cancers16244201.


Vitamin D in Cancer Prevention and Treatment: A Review of Epidemiological, Preclinical, and Cellular Studies.

Dallavalasa S, Tulimilli S, Bettada V, Karnik M, Uthaiah C, Anantharaju P Cancers (Basel). 2024; 16(18).

PMID: 39335182 PMC: 11430526. DOI: 10.3390/cancers16183211.


Vitamin D deficiency and the vitamin D receptor (VDR) gene polymorphism rs2228570 (FokI) are associated with an increased susceptibility to hypertension among the Bangladeshi population.

Nabil I, Mahmud Z, Tamanna S, Rahman M, Rashid G, Hossain M PLoS One. 2024; 19(3):e0297138.

PMID: 38483874 PMC: 10939211. DOI: 10.1371/journal.pone.0297138.


The Relationship between Gene Polymorphisms and with Breast Cancer Risk.

Mozaffarizadeh H, Mokarian F, Salehi M, Hakimian S, Moazam E, Amoozadehsamakoosh A Glob Med Genet. 2024; 11(1):69-75.

PMID: 38440355 PMC: 10911907. DOI: 10.1055/s-0044-1779040.


Immunohistochemical Expression of Vitamin D Receptor (VDR) in Urinary Bladder Squamous Cell Carcinoma.

Sharaf R, Eldin-Shibel P, Abd-El-Moeze N Turk Patoloji Derg. 2024; 1(1):109-116.

PMID: 38265102 PMC: 11131569. DOI: 10.5146/tjpath.2023.12863.