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Iron in Infection and Immunity

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Publisher Cell Press
Date 2013 May 21
PMID 23684303
Citations 611
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Abstract

Iron is an essential nutrient for both humans and pathogenic microbes. Because of its ability to exist in one of two oxidation states, iron is an ideal redox catalyst for diverse cellular processes including respiration and DNA replication. However, the redox potential of iron also contributes to its toxicity; thus, iron concentration and distribution must be carefully controlled. Given the absolute requirement for iron by virtually all human pathogens, an important facet of the innate immune system is to limit iron availability to invading microbes in a process termed nutritional immunity. Successful human pathogens must therefore possess mechanisms to circumvent nutritional immunity in order to cause disease. In this review, we discuss regulation of iron metabolism in the setting of infection and delineate strategies used by human pathogens to overcome iron-withholding defenses.

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References
1.
Mazmanian S, Ton-That H, Su K, Schneewind O . An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis. Proc Natl Acad Sci U S A. 2002; 99(4):2293-8. PMC: 122358. DOI: 10.1073/pnas.032523999. View

2.
Skaar E, Humayun M, Bae T, DeBord K, Schneewind O . Iron-source preference of Staphylococcus aureus infections. Science. 2004; 305(5690):1626-8. DOI: 10.1126/science.1099930. View

3.
Lechardeur D, Cesselin B, Liebl U, Vos M, Fernandez A, Brun C . Discovery of intracellular heme-binding protein HrtR, which controls heme efflux by the conserved HrtB-HrtA transporter in Lactococcus lactis. J Biol Chem. 2011; 287(7):4752-8. PMC: 3281666. DOI: 10.1074/jbc.M111.297531. View

4.
Skaar E, Gaspar A, Schneewind O . IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus. J Biol Chem. 2003; 279(1):436-43. DOI: 10.1074/jbc.M307952200. View

5.
Kirienko N, Kirienko D, Larkins-Ford J, Wahlby C, Ruvkun G, Ausubel F . Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host Microbe. 2013; 13(4):406-16. PMC: 3641844. DOI: 10.1016/j.chom.2013.03.003. View