Vaccine Assembly from Surface Proteins of Staphylococcus Aureus

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2006 Nov 1

PMID 17075065

Citations 155

Authors

Yukiko K Stranger-Jones

Taeok Bae

Olaf Schneewind

Affiliations

Soon will be listed here.

Abstract

Staphylococcus aureus is the most common cause of hospital-acquired infection. Because of the emergence of antibiotic-resistant strains, these infections represent a serious public health threat. To develop a broadly protective vaccine, we tested cell wall-anchored surface proteins of S. aureus as antigens in a murine model of abscess formation. Immunization with four antigens (IsdA, IsdB, SdrD, and SdrE) generated significant protective immunity that correlated with the induction of opsonophagocytic antibodies. When assembled into a combined vaccine, the four surface proteins afforded high levels of protection against invasive disease or lethal challenge with human clinical S. aureus isolates.

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